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Techniques in the Study of Blood Flow through both Constrictions and Post-Stenotic Dilatations in Arteries

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Computational Methods in Biophysics, Biomaterials, Biotechnology and Medical Systems

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35.1 9.1 Introduction

35.1.1 1.1 Motivation for application of modelling techniques

Coronary artery disease is the largest single cause of mortality in developed nations. In 1994 it was responsible for 24.13% of deaths in Australia, and 21.34% in the USA [59]. It occurs when the coronary arteries narrow to such an extent that they are unable to transport sufficient blood to the heart muscle for it to function efficiently. The two main causes of death from coronary artery disease are rupture of the plaque causing sudden occlusion of the artery and the slow build up of a stenosis in the artery due to atherosclerosis. Reduction in blood flow caused by stenosis build up also causes debilitation. There is considerable interest in techniques that predict the resistance to flow caused by the impingement of atherosclerotic lesions into the lumen and the subsequent extra shear stresses on the wall.

In spite of the large number of studies into the area the causes of arteriosclerosis are...

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  1. Cornelius T. Leondes
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Leondes, C.T. (2003). Techniques in the Study of Blood Flow through both Constrictions and Post-Stenotic Dilatations in Arteries. In: Leondes, C.T. (eds) Computational Methods in Biophysics, Biomaterials, Biotechnology and Medical Systems. Springer, Boston, MA. https://doi.org/10.1007/0-306-48329-7_35

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  • DOI: https://doi.org/10.1007/0-306-48329-7_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7110-2

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