Synonyms
AA metabolites, eicosonoids, PGG2 , prostaglandin G2 ,PGH2 , prostaglandin H2 , PGE2 , prostaglandin E2 , PGF2α , prostaglandin F2α , thromboxane A2 , TXA2 , prostacyclin, PGI2 ,5-HPETE, 15-HPETE, lipoxins, lipoxin A4, lipoxin B4, leukotriene A4 , LTA4 , leukotriene B4 , LTB4 , leukotriene C4 , LTC4 , leukotriene D4 , LTD4 , leukotriene E4 , LTE4 .
Definition
Biologically active products of the enzymatic cascade whereby cyclooxygenases (PGH synthases) and 5-lipooygenase incorporate arachidonic acid as the initial substrate. Subsequent sequential enzymatic reactions yield biologically active prostaglandins and leukotrienes.
Full Text
Following phospholipase mediated liberation of arachidonic acid from cell membrane phospholipids, arachidonic acid may be metabilized by cycooxygenase (PGH synthase) to yield PGG2; subsequent peroxidase activity yields PGH2which may then be used as a substrate by specific prostaglandin synthases to yield biologically active metabolites including...
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References
Lewis RA, Austen KF, Soberman RJ (1990) Leukotrienes and other products of the 5-lipooxygenase pathway. N Engl J Med 323:645–55
Needleman P, Turk J, Jakschik BA, Morrison AR, Lefkowith JB (1986) Arachidonic acid metabolism. Annu Rev Biochem 55:69–102
Robinson DR (1987) Lipid mediators of inflammation. Rheum Dis Clin North Am 13:1385–405
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© 2004 Springer-Verlag
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(2004). Arachidonic acid metabolites. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_294
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DOI: https://doi.org/10.1007/3-540-29662-X_294
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20625-5
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