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Activity on urinary tract1

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Drug Discovery and Evaluation

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1 C.1 Diuretic and saluretic activity

1.1 C.1.1 In vitro methods

1.1.1 C.1.1.1 Carbonic anhydrase inhibition in vitro

1.1.1.1 PURPOSE AND RATIONALE

Acetazolamide (Diamox®) was one of the first synthetic non-mercurial diuretics. The mode of action was found to be inhibition of carbonic anhydrase. Carbonic anhydrase is a zinc-containing enzyme that catalyzes the reversible hydration (or hydroxylation) of CO2 to form H2CO3 which dissociates non-enzymatically into HCO3 − and H+. At least three isoenzymes, designated as I, II and II or A, B and C, are known to exist. The chemistry, physiology and pharmacology of carbonic anhydrase has been extensively reviewed by Maren (1967). In spite of the fact that newer diuretics are based on other modes of action, the test for inhibition of carbonic anhydrase should be performed for evaluation of a new compound. Moreover, the specific use of carbonic anhydrase inhibitors as antiglaucoma drugs has been described (Friedland and Maren 1984; Caprioli...

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  1. Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    Prof. Dr. Dr. H. Gerhard Vogel

  2. Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA

    Prof. Dr. Wolfgang H. Vogel

  3. Aventis Deutschland GmbH, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt, Germany

    Prof. Dr. Bernward A. Schölkens & Prof. Dr. Jürgen Sandow

  4. Institut für Genetik, Avenfis Deutschland GmbH, Ludwig Maximilian-Universität München, München, Germany

    PD Dr. Günter Müller

  5. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada

    Dr. Wolfgang F. Vogel (Assistant Professor)

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  1. Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    H. Gerhard Vogel

  2. Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA

    Wolfgang H. Vogel

  3. Aventis Deutschland GmbH, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt, Germany

    Bernward A. Schölkens  & Jürgen Sandow  & 

  4. Institut für Genetik, Avenfis Deutschland GmbH, Ludwig Maximilian-Universität München, München, Germany

    Günter Müller

  5. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada

    Wolfgang F. Vogel (Assistant Professor) (Assistant Professor)

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Vogel, H.G., Vogel, W.H., Schölkens, B.A., Sandow, J., Müller, G., Vogel, W.F. (2002). Activity on urinary tract1 . In: Vogel, H.G., Vogel, W.H., Schölkens, B.A., Sandow, J., Müller, G., Vogel, W.F. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29837-1_4

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