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Gene Expression Arrays

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Encyclopedia of Database Systems

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Definition

A gene expression array (or DNA microarray) is a miniature, massively parallel, and semi-automated process that measures levels of gene products (or mRNA or transcripts). The DNA of an organism (cell or cells) is a set of instructions used to direct its existence. A genetic message is transcribed from DNA into mRNA (messenger RNA), then typically translated into protein. By measuring the levels of mRNA, an indirect glimpse can be taken into the functioning of a cell. The relative and absolute levels of the transcripts are called expressions, and this instantaneous set of expressions is called the expression profile. Profiles can be used, for example, to indicate a disease state.

Historical Background

DNA and RNA are bio-molecules that hybridizebonding due to complementary structure. Hybridization has been used for several decades as means of identifying DNA and RNA present in an organism (cell or cells). Until microarray technology was invented, utilizing hybridization was...

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Recommended Reading

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Author information

Authors and Affiliations

  1. Indiana University, Bloomington, IN, USA

    Mehmet M. Dalkiliç

Authors
  1. Mehmet M. Dalkiliç
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Editor information

Editors and Affiliations

  1. College of Computing, Georgia Institute of Technology, 266 Ferst Drive, 30332-0765, Atlanta, GA, USA

    LING LIU (Professor) (Professor)

  2. Database Research Group David R. Cheriton School of Computer Science, University of Waterloo, 200 University Avenue West, N2L 3G1, Waterloo, ON, Canada

    M. TAMER ÖZSU (Professor and Director, University Research Chair) (Professor and Director, University Research Chair)

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© 2009 Springer Science+Business Media, LLC

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Dalkiliç, M.M. (2009). Gene Expression Arrays. In: LIU, L., ÖZSU, M.T. (eds) Encyclopedia of Database Systems. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-39940-9_1435

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