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Ziprasidone

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Encyclopedia of Clinical Neuropsychology

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Generic Name

Ziprasidone

Brand Name

Geodon

Class

Atypical Neuroleptic

Proposed Mechanism(s) of Action

Blocks dopamine-2 receptors, blocks serotonin 2A receptors thus increasing presynaptic related catecholamine release.

Indication

Schizophrenia, delaying relapse in schizophrenia, acute agitation in schizophrenia, and acute mania.

Off Label Use

Psychotic disorders, bipolar maintenance, bipolar depression, behavioral disturbances associated with dementia and in children and adolescents, and impulse control disorders.

Side Effects

Serious

Seizures, neuroleptic malignant syndrome.

Common

Dizziness, extrapyramidal symptoms, sedation, nausea, dry mouth, skin rash, tardive dyskinesia, orthostatic hypotension, and activation effects.

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References and Readings

  • Physicians’ Desk Reference (62nd ed.). (2007). Montvale, NJ: Thomson PDR.

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  • Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York, NY: Cambridge University Press.

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Author information

Authors and Affiliations

  1. Department of Psychology, Children's Hospital of New Orleans, 200 Henry Clay Avenue, 70118, New Orleans, LA, USA

    John C. Courtney

  2. Mercy Family Center, 110 Vetrans Memorial Blvd, 70005, Metarie, LA, USA

    Cristy Akins

Authors
  1. John C. Courtney
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  2. Cristy Akins
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Editor information

Editors and Affiliations

  1. Physical Medicine and Rehabilitation, and Professor of Neurosurgery, and Psychiatry Virginia Commonwealth University – Medical Center Department of Physical Medicine and Rehabilitation, VCU, 980542, Richmond, Virginia, 23298-0542, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation Research Center, 1199 Pleasant Valley Way, West Orange, NJ, 07052, USA

    John DeLuca

  3. Professor of Physical Medicine and Rehabilitation, and Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey – New Jersey Medical School, New Jersey, USA

    John DeLuca

  4. Independent Practice, 564 M.O.B. East, 100 E. Lancaster Ave., Wynnewood, PA, 19096, USA

    Bruce Caplan

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© 2011 Springer Science+Business Media, LLC

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Courtney, J.C., Akins, C. (2011). Ziprasidone. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79948-3_1725

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  • DOI: https://doi.org/10.1007/978-0-387-79948-3_1725

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-79947-6

  • Online ISBN: 978-0-387-79948-3

  • eBook Packages: Behavioral Science

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