Synonyms
Renal
Definition
Vasculitis is a pathological process defined by leukocyte invasion and fibrinoid necrosis of the vessel wall. Any size vessel can be affected, and vasculitis may be associated with thrombotic occlusion, stenosis, or aneurysmal dilatation of the blood vessel.
Introduction
Systemic vasculitis occurs either as a primary autoimmune disorder or as a secondary manifestation of another disease process (Tables 1 and 2). Primary systemic vasculitis is classified according to the predominant size of vessel involved and the presence of circulating antineutrophil cytoplasmic autoantibodies (ANCA) (Fig. 1) (Jennette 2011; Watts et al. 2011). Small vessel vasculitides, especially those associated with ANCA, often involve the kidneys. Less commonly, large vessel vasculitides such as polyarteritis nodosa and Takayasu arteritis can involve the kidneys.
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References
Abdulahad WH, Stegeman CA, et al. Review article: the role of CD4(+) T cells in ANCA-associated systemic vasculitis. Nephrology (Carlton). 2009;14(1):26–32.
Berden A, Arda, G, Jagre D et al. Diagnosis and the management of ANCA associated vasculitis. BMJ, 2012;344:e26.
Coppo R, Amore A, et al. Clinical features of Henoch-Schonlein purpura. Italian Group of Renal Immunopathology. Ann Med Interne (Paris). 1999;150(2):143–50.
de Groot K, Adu D, et al. The value of pulse cyclophosphamide in ANCA-associated vasculitis: meta-analysis and critical review. Nephrol Dial Transplant. 2001;16(10):2018–27.
De Groot K, Rasmussen N, et al. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2005;52(8):2461–9.
Flossmann O, Berden A, et al. Long-term patient survival in ANCA-associated vasculitis. Ann Rheum Dis. 2011;70:488–94.
Hamano Y, Tsukamoto K, et al. Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. J Immunol. 2006;176(6):3662–73.
Hellmich B, Flossmann O, et al. EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis. Ann Rheum Dis. 2007;66(5):605–17. Epub 2006 Dec 2014.
Hewins P, Savage CO. ANCA and neutrophil biology. Kidney Blood Press Res. 2003;26(4):221–5.
Hogan SL, Cooper GS, et al. Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study. Clin J Am Soc Nephrol. 2007;2(2):290–9. Epub 2007 Feb 2007.
Jayne D, Rasmussen N, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med. 2003;349(1):36–44.
Jayne DR, Gaskin G, et al. Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am Soc Nephrol. 2007;20:20.
Jennette JC. Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener’s granulomatosis). Clin Exp Immunol. 2011;164(Suppl):7–10.
Jennette JC, Falk RJ, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994;37(2):187–92.
Jones RB, Cohen Tervaert JW, et al. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N Engl J Med. 2010;363:211–20.
Kallenberg CGM. Pathogenesis of ANCA-associated vasculitis, an update. Clin Rev Allergy Immunol. 2011;41(2):224–31.
Lane SE, Watts R, et al. Epidemiology of systemic vasculitis. Curr Rheumatol Rep. 2005;7(4):270–5.
Levy JB, Hammad T, et al. Clinical features and outcome of patients with both ANCA and anti-GBM antibodies. Kidney Int. 2004;66(4):1535–40.
Savage COS. Pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis. Clin Exp Immunol. 2011;164(Suppl):23–6.
Savige J, Gillis D, et al. International consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies (ANCA). Am J Clin Pathol. 1999;111(4):507–13.
Schmitt WH, van der Woude FJ. Organ transplantation in the vasculitides. Curr Opin Rheumatol. 2003;15(1):22–8.
Stegeman CA, Tervaert JW, et al. Association of chronic nasal carriage of Staphylococcus aureus and higher relapse rates in Wegener granulomatosis. Ann Intern Med. 1994;120(1):12–7.
Stone JH, Merkel PA, et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med. 2010;363:221–32.
Walsh M, Floßmann O et al. Risk factors for relapse of ANCA associated vasculitis. Arthritis Rheum. 2012;64:S42–S48.
Watts RA, Suppiah R, et al. Systemic vasculitis–is it time to reclassify? Rheumatology (Oxford). 2011;50(4):643–5.
Weyand CM, Goronzy JJ. Giant-cell arteritis and polymyalgia rheumatica. Ann Intern Med. 2003;139(6):505–15.
Xiao H, Heeringa P, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest. 2002;110(7):955–63.
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Yew, S., Jayne, D. (2014). Vasculitis and the Kidney. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_56
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DOI: https://doi.org/10.1007/978-0-387-84828-0_56
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