Definition
Na+/glucose cotransporters (SGLTs) are responsible for the “secondary-active” transport of glucose and other substrates across cellular membranes. They concentrate glucose inside the cell using electrochemical energy from the transmembrane Na+ gradient, employing an alternating access cotransport mechanism. Their most important roles are to mediate the absorption of glucose in the intestine and its reabsorption in the proximal tubules of the kidney.
Introduction
The general mechanism for active glucose cotransport through epithelial cells was first proposed by Robert Crane in the early 1960s. It described the secondary-active pumping of glucose across the brush border membrane of the intestinal epithelium using the Na+ gradient generated by the basolateral Na+/K+-ATPase....
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References
Abramson J, Wright EM (2009) Structure and function of Na + -symporters with inverted repeats. Curr Opin Struct Biol 19(4):425–432
Bergeron M, Goodyer PR, Gougoux A, Lapointe JY (2000) Pathophysiology of renal hyperaminoacidurias and glucosuria. In: Giebish DWSG (ed) The Kidney, vol 2, 3rd edn. Lippincott Williams & Wilkins, New-York, pp 2211–2233
Bizhanova A, Kopp P (2009) The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology 150(3):1084
Boudker O, Verdon G (2010) Structural perspectives on secondary active transporters. Trend Pharmacol Sci 31(9):418–426
Chao EC, Henry RR (2010) SGLT2 inhibition – a novel strategy for diabetes treatment. Nat Rev Drug Discov 9(7):551–559
Coady MJ, Wallendorff B et al (2007) Establishing a definitive stoichiometry for the Na+/monocarboxylate cotransporter SMCT1. Biophys J 93(7):2325–2331
Dieter M, Palmada M et al (2004) Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB* &ast. Obesity 12(5):862–870
Forrest LR, Krämer R et al (2010) The structural basis of secondary active transport mechanisms. Biochim Biophys Acta (BBA) Bioenergetics 1807:167–188
Ganapathy V, Thangaraju M et al (2008) Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J 10(1):193–199
Lahjouji K, Aouameur R et al (2007) Expression and functionality of the Na+/myo-inositol cotransporter SMIT2 in rabbit kidney. Biochim Biophys Acta (BBA)-Biomembranes 1768(5):1154–1159
Leung D, Turk E et al (2002) Functional expression of the vibrio parahaemolyticus Na+/galactose (vSGLT) cotransporter in xenopus laevis oocytes. J Membr Biol 187(1):65–70
Prasad PD, Ganapathy V (2000) Structure and function of mammalian sodium-dependent multivitamin transporter. Curr Opin Clin Nutr Metab Care 3(4):263
Ribeiro FM, Black SAG et al (2006) The “ins” and “outs” of the high affinity choline transporter CHT1. J Neurochem 97(1):1–12
Sabino-Silva R, Mori R et al (2010) The Na+/glucose cotransporters: from genes to therapy. Braz J Med Biol Res 43(11):1019–1026
Tazawa S, Yamato T et al (2005) SLC5A9/SGLT4, a new Na + -dependent glucose transporter, is an essential transporter for mannose, 1, 5-anhydro-D-glucitol, and fructose. Life Sci 76(9):1039–1050
Wright EM, Turk E (2004) The sodium/glucose cotransport family SLC5. Pflügers Archiv Eur J Physiol 447(5):510–518
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Sasseville, L.J., Lapointe, JY. (2013). Sodium/Glucose Co-transporters, Structure and Function. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_245
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DOI: https://doi.org/10.1007/978-1-4614-1533-6_245
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