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Reelin

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

Synonyms

ETL7; LIS2; PRO1598; RELN; RL

Historical Background

In 1951, Falconer reported a spontaneous autosomal recessive mutant mouse, known as reeler, that exhibited ataxia, tremor, and a “reeling” gait (Falconer 1951). The responsible gene of this mutant mouse was subsequently identified and named reelin more than 40 years later (Bar et al. 1995; D’Arcangelo et al. 1995; Hirotsune et al. 1995). Since then, histological studies on reeler have clarified several malformations in brain organization including a disrupted architecture, abnormal layer formation, and aberrant neuronal positioning in various brain regions, such as the olfactory bulb, neocortex, hippocampus, cerebellum, several brainstem nuclei, and spinal cord (reviewed in Katsuyama and Terashima 2009). One of the characteristic features of the reeler brain is the roughly inverted laminar structure in the neocortex and hippocampus. These observations led to the hypothesis that the reelermalformation is caused by a...

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Authors and Affiliations

  1. Department of Anatomy, Keio University School of Medicine, Tokyo, Japan

    Kanehiro Hayashi, Seika Inoue & Kazunori Nakajima

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  1. Kanehiro Hayashi
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  2. Seika Inoue
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Correspondence to Kazunori Nakajima .

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  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Hayashi, K., Inoue, S., Nakajima, K. (2018). Reelin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101808-1

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