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Neuron-Glial Interactions

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Encyclopedia of Computational Neuroscience

Synonyms

Axon-glial signaling; Computational glioscience; Microglia modeling; Neuron-glial interaction modeling; Synapse-astrocyte bidirectional signaling

Definition

Dependence of neuronal function on glial cells and vice versa, which consists of the interplay of potentially multiple signals that can be both of neuronal and of glial origin. This interplay may be facilitated by the specific arrangement of neurons versus glia in different brain areas and occurs on time scales extending from milliseconds to months, as well as on spatial scales ranging from subcellular and synaptic levels to those of networks and whole-brain structures.

Detailed description

Most animals share the ability to move in response to external stimuli, which results from having developed complex neural structures that allow for sophisticated processing of sensory information. From a phylogenetic perspective, as the nervous system changed from a simple net-like structure, such as in jellyfish (Cnidara), to...

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Acknowledgments

Writing of this chapter was made possible by the generous support of the Junior Leader Fellowship Program by “la Caixa” Banking Foundation (LCF/BQ/LI18/11630006), as well as by the support of the Basque Government through the BERC 2018–2012 program, and by the Spanish Ministry of Science, Innovation and Universities: BCAM Severo Ochoa Accreditation SEV-2017-0718.

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    Maurizio De Pittà

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    Sharmila Venugopal Assistant Research Professor

  2. Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX, USA

    Rahul Srinivasan

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De Pittà, M. (2020). Neuron-Glial Interactions. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_100691-1

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