Skip to main content
SpringerLink
Log in

Connectome, Mouse

  • Living reference work entry
  • First Online:
Encyclopedia of Computational Neuroscience

  • 243 Accesses

Definition

The mouse connectome is a collection of all neuronal connections in the mouse brain, i.e., a complete wiring diagram of the mouse brain.

Detailed Description

The concept of connectome (Sporns et al. 2005; Seung 2012; Sporns 2012) has rapidly grown into a central theme in neuroscience and specifically in computational neuroscience and computational neuroanatomy. So far, as of 2013, the only existing connectome is that of the nematode C. elegans (White et al. 1986). Once obtained, the connectome of the mouse is expected to have significant scientific and clinical impact, due to (1) strong architectural and genetic similarities between the mouse and humans, (2) the extensive body of experimental studies involving the organism, and (3) the availability of a large array of transgenic, knockin, and knockout variants and molecular probes to infer function from the connectome structure (Chinwalla et al. 2002).

Acquisition of the Mouse Connectome

Rapid development in imaging...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Allen Institute for Brain Science (2012) ALLEN mouse brain connectivity atlas technical white paper: overview. Technical report October 2012 v.4. Allen Institute for Brain Science. http://connectivity.brain-map.org

  • Bock DD, Kerlin AM, Andermann ML, Hood G, Wetzel AW, Yurgenson S, Soucy ER, Kim HS, Reid RC (2011) Network anatomy and in vivo physiology of visual cortical neurons. Nature 471:177–182

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Chinwalla AT, Cook LL, Delehaunty KD, Fewell GA, Fulton LA, Fulton RS, Mauceli E (2002) Initial sequencing and comparative analysis of the mouse genome. Nature, 420(6915), 520–562

    Article  PubMed  Google Scholar 

  • Chung JR, Sung C, Mayerich D, Kwon J, Miller DE, Huffman T, Abbott LC, Keyser J, Choe Y (2011) Multiscale exploration of mouse brain microstructures using the knife-edge scanning microscope brain atlas. Front Neuroinform 5:29

    PubMed Central  PubMed  Google Scholar 

  • Grange P, Mitra PP (2011) Algorithmic choice of coordinates for injections into the brain: encoding a neuroanatomical atlas on a grid. arXiv:1104.2616v1 [q-Bio.QM]

    Google Scholar 

  • Hintiryan H, Gou L, Zingg B, Yamashita S, Lyden HM, Song MY, Grewal AK, Zhang X, Toga AW, Dong H-W (2012) Comprehensive connectivity of the mouse main olfactory bulb: analysis and online digital atlas. Front Neuroanat 6:30. doi:10.3389/fnana.2012.00030

    Article  PubMed Central  PubMed  Google Scholar 

  • Mayerich D, Abbott LC, McCormick BH (2008) Knife-edge scanning microscopy for imaging and reconstruction of three-dimensional anatomical structures of the mouse brain. J Microsc 231:134–143

    Article  CAS  PubMed  Google Scholar 

  • Mikula S, Binding J, Denk W (2012) Staining and embedding the whole mouse brain for electron microscopy. Nat Methods 9:1198–1201

    Article  CAS  PubMed  Google Scholar 

  • Mitra PP (2012) Technical white paper: mouse brain architecture project. Technical report, Cold Spring Harbor Laboratory. http://brainarchitecture.org/mouse/documentation/project-white-paper

  • Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates, 2nd edn. Academic, San Diego

    Google Scholar 

  • Ragan T, Kadiri LR, Venkataraju KU, Bahlmann K, Sutin J, Taranda J, Arganda-Carreras I, Kim Y, Seung HS, Osten P (2012) Serial two-photon tomography for automated ex vivo mouse brain imaging. Nat Methods 9:255–258

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Seung HS (2012) Connectome: how the brain’s wiring makes us who we are. Houghton Mifflin Harcourt, Boston

    Google Scholar 

  • Sporns O (2012) Discovering the human connectome. MIT Press, Cambridge, MA

    Google Scholar 

  • Sporns O, Tononi G, Kötter R (2005) The human connectome: a structural description of the human brain. PLoS Comput Biol 1:e42

    Article  PubMed Central  PubMed  Google Scholar 

  • White JG, Southgate E, Thomson JN, Brenner S (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc Lond B 314:1–340

    Article  CAS  Google Scholar 

  • Zingg B, Hintiryan H, Gou L, Song MY, Bay M, Bienkowski MS, Dong HW (2014) Neural Networks of the Mouse Neocortex. Cell, 156(5), 1096–1111

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Computer Science and Engineering, Texas A&M University, College Station, TX, USA

    Yoonsuck Choe

  2. Department of Electrical and Computer Engineering, Kettering University, 1700 University Ave, Flint, MI, 48504, USA

    Jaerock Kwon

  3. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 N. Matthews Ave, Urbana, IL, 61801, USA

    David Mayerich Ph.D. in Computer Science

  4. Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA

    Louise C. Abbott

Authors
  1. Yoonsuck Choe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jaerock Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Mayerich Ph.D. in Computer Science
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Louise C. Abbott
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yoonsuck Choe .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this entry

Cite this entry

Choe, Y., Kwon, J., Mayerich, D., Abbott, L.C. (2014). Connectome, Mouse. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_276-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_276-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation