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Long Term Depression in the Granule Cell-Purkinje Cell Synapse

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Encyclopedia of Computational Neuroscience

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Synonyms

Cerebellar long-term depression; Cerebellar LTD; Long-term synaptic depression at the parallel fiber-Purkinje cell synapse

Definition

Long-term depression (LTD) in the granule cell-Purkinje cell synapse is a reduction of synaptic transmission efficacy, which lasts for hours or longer. The synaptic transmission at this synapse is mediated via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), a member of the ionotropic glutamate receptors, and the direct cause of LTD is a reduction in the numbers of postsynaptic AMPARs. The traditional stimulation to trigger LTD is simultaneous and repeated activation of two excitatory inputs onto Purkinje cells, parallel fibers (PFs) and climbing fibers (CFs), which are neuronal projections originated from granule cells and neurons in inferior olivary nucleus, respectively.

Detailed Description

The LTD at synapses between PFs, axons of granule cells, and Purkinje cells (Fig. 1) was first discovered in the 1980s, and the...

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Authors and Affiliations

  1. Center for Functional Connectomics, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, 136-791, Seoul, Republic of Korea

    Keiko Tanaka-Yamamoto

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  1. Keiko Tanaka-Yamamoto
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Correspondence to Keiko Tanaka-Yamamoto .

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Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Tanaka-Yamamoto, K. (2014). Long Term Depression in the Granule Cell-Purkinje Cell Synapse. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_472-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_472-1

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  • Online ISBN: 978-1-4614-7320-6

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