Synonyms
Definition
The ABC transporters represent one of the largest families of transmembrane proteins in most organisms including plants, bacteria, and eukaryotic cells. They perform numerous key physiological processes directly coupled with the hydrolysis of ATP. From the pharmacological point of view, ABC transporters are of special interest because of their relevance in transmembrane transport of various drugs, thereby modifying intracellular concentrations and hence effects of these compounds. Furthermore, they represent potential target structures to interfere with (patho-)physiological processes in which they are involved.
Basic Characteristics
ATP-binding cassette (ABC) proteins are present in plants, bacteria, and eukaryotic organisms including mammalians. In humans the ABC gene superfamily comprises about 50 members, which are organized in 7 subfamilies called ABCA to ABCG on the basis of their domain organization and phylogenetic...
References
Aikawa T, Holm ML, Kanekiyo T (2018) ABCA7 and pathogenic pathways of Alzheimer’s disease. Brain Sci 8:27
Beis K (2015) Structural basis for the mechanism of ABC transporters. Biochem Soc Trans 43:889–893
Belleville-Rolland T, Sassi Y, Decouture B, Dreano E, Hulot JS, Gaussem P, Bachelot-Loza C (2016) MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease. Pharmacol Res 107:381–389
Berical A, Lee RE, Randell SH, Hawkins F (2019) Challenges facing airway epithelial cell-based therapy for cystic fibrosis. Front Pharmacol 10:74
Borst P, Elferink RO (2002) Mammalian ABC transporters in health and disease. Annu Rev Biochem 71:537–592
Bruhn O, Cascorbi I (2014) Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance. Expert Opin Drug Metab Toxicol 10:1337–1354
Chan LM, Lowes S, Hirst BH (2004) The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci 21:25–51
Chen Z, Shi T, Zhang L, Zhu P, Deng M, Huang C, Hu T, Jiang L, Li J (2016) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: a review of the past decade. Cancer Lett 370:153–164
Gottesman MM, Ling V (2006) The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett 580:998–1009
Ishikawa T, Toyoda Y, Yoshiura K, Niikawa N (2013) Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion. Front Genet 3:306
Jansen RS, Kucukosmanoglu A, de Haas M, Sapthu S, Otero JA, Hegman IE, Bergen AA, Gorgels TG, Borst P, van de Wetering K (2013) ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci U S A 110:20206–20211
Keppler D (2011) Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy. Handb Exp Pharmacol 2011:299–323
Lund M, Petersen TS, Dalhoff KP (2017) Clinical implications of P-glycoprotein modulation in drug-drug interactions. Drugs 77:859–883
Mao Q, Unadkat JD (2015) Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport–an update. AAPS J 17:65–82
Slot AJ, Molinski SV, Cole SP (2011) Mammalian multidrug-resistance proteins (MRPs). Essays Biochem 50:179–207
Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT (2015) Impact of genetic polymorphisms of ABCB1 (MDR1, P-glycoprotein) on drug disposition and potential clinical implications: update of the literature. Clin Pharmacokinet 54:709–735
Zhou SF, Wang LL, Di YM, Xue CC, Duan W, Li CG, Li Y (2008) Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem 15:1981–2039
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Grube, M., Jedlitschky, G. (2020). ABC Transporters. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-21573-6_174-1
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DOI: https://doi.org/10.1007/978-3-030-21573-6_174-1
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