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Sarcopenic Obesity

Metabolic Syndrome
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Abstract

An aging population in conjunction with a worsening obesity epidemic worldwide is leading to a public health epidemic of older adults with considerable mobility limitations. Loss of muscle mass and function with age is termed sarcopenia and is a natural phenomenon of the aging process, which is aggravated with coexistent obesity. These persons with sarcopenic obesity are thought to be at higher risk of adverse outcomes than of people with either sarcopenia or obesity alone. Emerging consensus in identifying patients will provide a standardized manner in developing clinical trials that will lead to modification of body composition and improvement of physical function. Recommended multicomponent management strategies consisting of dietary and exercise modifications are safely recommended for weight loss and mitigation of worsening of sarcopenia. Promising and emerging therapies have potential to alter body composition and muscle physiology with a goal of improving primary and secondary outcomes in this subgroup of patients.

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Abbreviations

BMI:

Body mass index

FNIH:

Foundation for the National Institutes of Health

NHANES:

National Health and Nutrition Examination Survey

SarcO:

Sarcopenic obesity

References

  • Abellan van Kan G, Rolland YM, Morley JE, Vellas B (2008) Frailty: toward a clinical definition. Journal of the American Medical Directors Association 9 (2):71–72. doi:10.1016/j.jamda.2007.11.005

    Article  PubMed  Google Scholar 

  • Alley DE, Shardell MD, Peters KW, McLean RR, Dam TT, Kenny AM, Fragala MS, Harris TB, Kiel DP, Guralnik JM, Ferrucci L, Kritchevsky SB, Studenski SA, Vassileva MT, Cawthon PM (2014) Grip strength cutpoints for the identification of clinically relevant weakness. The journals of gerontology Series A, Biological sciences and medical sciences 69 (5):559–566. doi:10.1093/gerona/glu011

    Article  PubMed Central  PubMed  Google Scholar 

  • Ambrose NL, Keogan F, O’Callaghan JP, O’Connell PG (2010) Obesity and disability in the symptomatic Irish knee osteoarthritis population. Irish journal of medical science 179 (2):265–268. doi:10.1007/s11845-009-0459-5

    Article  CAS  PubMed  Google Scholar 

  • American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc 2012; J Am Geriatr Soc. 2012 Oct;60(10):E1–E25

    Google Scholar 

  • American Geriatrics Society Workgroup on Vitamin DSfOA (2014) Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for Prevention of Falls and Their Consequences. Journal of the American Geriatrics Society 62 (1):147–152. doi:10.1111/jgs.12631

    Google Scholar 

  • American Geriatrics Society Workgroup on Vitamin DSfOA (2014) Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for Prevention of Falls and Their Consequences. Journal of the American Geriatrics Society 62 (1):147–152. doi:10.1111/jgs.12631

    Google Scholar 

  • Atherton PJ, Smith K (2012) Muscle protein synthesis in response to nutrition and exercise. J Physiol 590 (Pt 5):1049–1057. doi:10.1113/jphysiol.2011.225003

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2014) Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. Journal of the American Geriatrics Society 62 (2):253–260. doi:10.1111/jgs.12652

    Article  PubMed  Google Scholar 

  • Auyeung TW, Lee JS, Leung J, Kwok T, Woo J (2013) Adiposity to muscle ratio predicts incident physical limitation in a cohort of 3,153 older adults – an alternative measurement of sarcopenia and sarcopenic obesity. Age (Dordr) 35 (4):1377–1385. doi:10.1007/s11357-012-9423-9

    Article  CAS  Google Scholar 

  • Baek SJ, Nam GE, Han KD, Choi SW, Jung SW, Bok AR, Kim YH, Lee KS, Han BD, Kim DH (2014) Sarcopenia and sarcopenic obesity and their association with dyslipidemia in Korean elderly men: the 2008–2010 Korea National Health and Nutrition Examination Survey. J Endocrinol Invest 37 (3):247–260. doi:10.1007/s40618-013-0011-3

    Article  CAS  PubMed  Google Scholar 

  • Baker WL, Karan S, Kenny AM (2011) Effect of dehydroepiandrosterone on muscle strength and physical function in older adults: a systematic review. Journal of the American Geriatrics Society 59 (6):997–1002. doi:10.1111/j.1532-5415.2011.03410.x

    Article  PubMed  Google Scholar 

  • Batsis JA, Barre LK, Mackenzie TA, Pratt SI, Lopez-Jimenez F, Bartels SJ (2013a) Variation in the prevalence of sarcopenia and sarcopenic obesity in older adults associated with different research definitions: dual-energy X-ray absorptiometry data from the National Health and Nutrition Examination Survey 1999–2004. Journal of the American Geriatrics Society 61 (6):974–980. doi:10.1111/jgs.12260

    Google Scholar 

  • Batsis JA, Huyck KL, Bartels SJ (2014a) Challenges with the Medicare Obesity Benefit: Practical Concerns & Proposed Solutions. Journal of general internal medicine. doi:10.1007/s11606-014-3031-6

    Google Scholar 

  • Batsis JA, Lopez-Jimenez F (2010) Cardiovascular risk assessment – from individual risk prediction to estimation of global risk and change in risk in the population. BMC medicine 8:29. doi:10.1186/1741-7015-8-29

    Article  PubMed Central  PubMed  Google Scholar 

  • Batsis JA, Nieto-Martinez RE, Lopez-Jimenez F (2007) Metabolic syndrome: from global epidemiology to individualized medicine. Clinical pharmacology and therapeutics 82 (5):509–524. doi:10.1038/sj.clpt.6100355

    Article  CAS  PubMed  Google Scholar 

  • Batsis JA, Sahakyan KR, Rodriguez-Escudero JP, Bartels SJ, Lopez-Jimenez F (2014b) Normal weight obesity and functional outcomes in older adults. Eur J Intern Med 25 (6):517–522. doi:10.1016/j.ejim.2014.05.008

    Google Scholar 

  • Batsis JA, Sahakyan KR, Rodriguez-Escudero JP, Bartels SJ, Somers VK, Lopez-Jimenez F (2013b) Normal weight obesity and mortality in United States subjects >/=60 years of age (from the Third National Health and Nutrition Examination Survey). The American journal of cardiology 112 (10):1592–1598. doi:10.1016/j.amjcard.2013.07.014

    Article  PubMed  Google Scholar 

  • Batsis JA, Zhbelik AJ, Scherer E, Barre LK, Bartels S (2015) Normal Weight Central Obesity, Physical Activity, and Functional Decline: Data from the Osteoarthritis Initiative. Journal of the American Geriatrics Society:[In-Press]

    Google Scholar 

  • Baumgartner RN (2000) Body composition in healthy aging. Annals of the New York Academy of Sciences 904:437–448

    Article  CAS  PubMed  Google Scholar 

  • Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. American Journal of Epidemiology 147 (8):755–763

    Article  CAS  PubMed  Google Scholar 

  • Baumgartner RN, Wayne SJ, Waters DL, Janssen I, Gallagher D, Morley JE (2004) Sarcopenic obesity predicts Instrumental Activities of Daily Living disability in the elderly. Obes Res 12 (12):1995–2004. doi:10.1038/oby.2004.250

    Article  PubMed  Google Scholar 

  • Beavers KM, Beavers DP, Nesbit BA, Ambrosius WT, Marsh AP, Nicklas BJ, Rejeski WJ (2014) Effect of an 18-month physical activity and weight loss intervention on body composition in overweight and obese older adults. Obesity (Silver Spring, Md) 22 (2):325–331. doi:10.1002/oby.20607

    Article  Google Scholar 

  • Behre HM, Tammela TL, Arver S, Tolra JR, Bonifacio V, Lamche M, Kelly J, Hiemeyer F, European Testogel Study T, Giltay EJ, Gooren LJ (2012) A randomized, double-blind, placebo-controlled trial of testosterone gel on body composition and health-related quality-of-life in men with hypogonadal to low-normal levels of serum testosterone and symptoms of androgen deficiency over 6 months with 12 months open-label follow-up. Aging Male 15 (4):198–207. doi:10.3109/13685538.2012.699562

    Google Scholar 

  • Bouchard DR, Dionne IJ, Brochu M (2009) Sarcopenic/Obesity and Physical Capacity in Older Men and Women: Data From the Nutrition as a Determinant of Successful Aging (NuAge)-the Quebec Longitudinal Study. Obesity 17 (11):2082–2088. doi:10.1038/oby.2009.109

    Article  PubMed  Google Scholar 

  • Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, Ziegenfuss T (2008) Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Int J Sport Nutr Exerc Metab 18 (4):389–398

    CAS  PubMed  Google Scholar 

  • Cawthon PM, Peters KW, Shardell MD, McLean RR, Dam TT, Kenny AM, Fragala MS, Harris TB, Kiel DP, Guralnik JM, Ferrucci L, Kritchevsky SB, Vassileva MT, Studenski SA, Alley DE (2014) Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. The journals of gerontology Series A, Biological sciences and medical sciences 69 (5):567–575. doi:10.1093/gerona/glu023

    Article  PubMed Central  PubMed  Google Scholar 

  • Census Bureau Statistics. (2012) United States Government. http://www.census.gov. Accessed January 20th, 2013 2013

  • Centers for Disease Control Vital Statistics. (2012) United States Government. http://www.cdc.gov. Accessed February 6th, 2015 2013

  • Chambers BA, Guo SS, Siervogel R, Hall G, Chumlea WC (2002) Cumulative effects of cardiovascular disease risk factors on quality of life. J Nutr Health Aging 6 (3):179–184

    CAS  PubMed  Google Scholar 

  • Chang CI, Huang KC, Chan DC, Wu CH, Lin CC, Hsiung CA, Hsu CC, Chen CY (2014) The impacts of sarcopenia and obesity on physical performance in the elderly. Obes Res Clin Pract. doi:10.1016/j.orcp.2014.08.003

    Google Scholar 

  • Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M (2010) Sarcopenia: European consensus on definition and diagnosis. Age Ageing 39 (4):412–423. doi:10.1093/ageing/afq034

    Article  PubMed Central  PubMed  Google Scholar 

  • Dam TT, Peters KW, Fragala M, Cawthon PM, Harris TB, McLean R, Shardell M, Alley DE, Kenny A, Ferrucci L, Guralnik J, Kiel DP, Kritchevsky S, Vassileva MT, Studenski S (2014) An evidence-based comparison of operational criteria for the presence of sarcopenia. The journals of gerontology Series A, Biological sciences and medical sciences 69 (5):584–590. doi:10.1093/gerona/glu013

    Article  PubMed Central  PubMed  Google Scholar 

  • Davison KK, Ford ES, Cogswell ME, Dietz WH (2002) Percentage of body fat and body mass index are associated with mobility limitations in people aged 70 and older from NHANES III. Journal of the American Geriatrics Society 50 (11):1802–1809

    Article  PubMed  Google Scholar 

  • Dunlop DD, Hughes SL, Manheim LM (1997) Disability in activities of daily living: patterns of change and a hierarchy of disability. American journal of public health 87 (3):378–383

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Emmelot-Vonk MH, Verhaar HJ, Nakhai Pour HR, Aleman A, Lock TM, Bosch JL, Grobbee DE, van der Schouw YT (2008) Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA : the journal of the American Medical Association 299 (1):39–52. doi:10.1001/jama.2007.51

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Balsells MM, Murad MH, Lane M, Lampropulos JF, Albuquerque F, Mullan RJ, Agrwal N, Elamin MB, Gallegos-Orozco JF, Wang AT, Erwin PJ, Bhasin S, Montori VM (2010) Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. The Journal of clinical endocrinology and metabolism 95 (6):2560–2575. doi:10.1210/jc.2009-2575

    Article  CAS  PubMed  Google Scholar 

  • Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL (1998) Overweight and obesity in the United States: prevalence and trends, 1960–1994. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 22 (1):39–47

    Article  CAS  Google Scholar 

  • Flegal KM, Graubard BI, Williamson DF, Gail MH (2005) Excess deaths associated with underweight, overweight, and obesity. JAMA : the journal of the American Medical Association 293 (15):1861–1867. doi:10.1001/jama.293.15.1861

    Article  CAS  PubMed  Google Scholar 

  • Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, Giles WH, Capewell S (2007) Explaining the decrease in U.S. deaths from coronary disease, 1980–2000. The New England journal of medicine 356 (23):2388–2398. doi:10.1056/NEJMsa053935

    Article  CAS  PubMed  Google Scholar 

  • Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA, Cardiovascular Health Study Collaborative Research G (2001) Frailty in older adults: evidence for a phenotype. The journals of gerontology Series A, Biological sciences and medical sciences 56 (3):M146–156

    Article  CAS  PubMed  Google Scholar 

  • Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP, American College of Sports M (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Medicine and science in sports and exercise 43 (7):1334–1359. doi:10.1249/MSS.0b013e318213fefb

    Google Scholar 

  • Gregg EW, Cheng YJ, Cadwell BL, Imperatore G, Williams DE, Flegal KM, Narayan KM, Williamson DF (2005) Secular trends in cardiovascular disease risk factors according to body mass index in US adults. JAMA : the journal of the American Medical Association 293 (15):1868–1874. doi:10.1001/jama.293.15.1868

    Article  CAS  PubMed  Google Scholar 

  • Guiding principles for the care of older adults with multimorbidity: an approach for c (2012) Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. Journal of the American Geriatrics Society 60 (10):E1–E25. doi:10.1111/j.1532-5415.2012.04188.x

    Google Scholar 

  • Hamrick MW, Herberg S, Arounleut P, He HZ, Shiver A, Qi RQ, Zhou L, Isales CM, Mi QS (2010) The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. Biochem Biophys Res Commun 400 (3):379–383. doi:10.1016/j.bbrc.2010.08.079

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hassing LB, Dahl AK, Thorvaldsson V, Berg S, Gatz M, Pedersen NL, Johansson B (2009) Overweight in midlife and risk of dementia: a 40-year follow-up study. International journal of obesity 33 (8):893–898. doi:10.1038/ijo.2009.104

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Heath JM, Stuart MR (2002) Prescribing exercise for frail elders. J Am Board Fam Pract 15 (3):218–228

    PubMed  Google Scholar 

  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine S (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism 96 (7):1911–1930. doi:10.1210/jc.2011-0385

    Article  CAS  PubMed  Google Scholar 

  • Houston DK, Ding J, Nicklas BJ, Harris TB, Lee JS, Nevitt MC, Rubin SM, Tylavsky FA, Kritchevsky SB, Health ABCS (2009) Overweight and obesity over the adult life course and incident mobility limitation in older adults: the health, aging and body composition study. American journal of epidemiology 169 (8):927–936. doi:10.1093/aje/kwp007

    Article  PubMed Central  PubMed  Google Scholar 

  • Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R (2004) The healthcare costs of sarcopenia in the United States. Journal of the American Geriatrics Society 52 (1):80–85

    Article  PubMed  Google Scholar 

  • Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 19 (4):385–397. doi:10.1007/s00198-007-0543-5

    Article  CAS  Google Scholar 

  • Katz S, Branch LG, Branson MH, Papsidero JA, Beck JC, Greer DS (1983) Active life expectancy. The New England journal of medicine 309 (20):1218–1224. doi:10.1056/nejm198311173092005

    Article  CAS  PubMed  Google Scholar 

  • Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of Illness in the Aged. The Index of ADL: A Standardized Measure of Biological and Psychosocial Function. JAMA : the journal of the American Medical Association 185:914–919

    Article  CAS  PubMed  Google Scholar 

  • Kim TN, Park MS, Ryu JY, Choi HY, Hong HC, Yoo HJ, Kang HJ, Song W, Park SW, Baik SH, Newman AB, Choi KM (2014) Impact of Visceral Fat on Skeletal Muscle Mass and Vice Versa in a Prospective Cohort Study: The Korean Sarcopenic Obesity Study (KSOS). PloS one 9 (12):e115407. doi:10.1371/journal.pone.0115407

    Article  PubMed Central  PubMed  Google Scholar 

  • Kim TN, Yang SJ, Yoo HJ, Lim KI, Kang HJ, Song W, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM (2009) Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study. Int J Obes 33 (8):885–892. doi:10.1038/ijo.2009.130

    Article  CAS  Google Scholar 

  • Kob R, Bollheimer LC, Bertsch T, Fellner C, Djukic M, Sieber CC, Fischer BE (2015) Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis? Biogerontology 16 (1):15–29. doi:10.1007/s10522-014-9539-7

    Article  CAS  PubMed  Google Scholar 

  • Kramer CK, Zinman B, Retnakaran R (2013) Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis. Annals of internal medicine 159 (11):758–769. doi:10.7326/0003-4819-159-11-201312030-00008

    Article  PubMed  Google Scholar 

  • Kuk JL, Ardern CI (2009) Influence of age on the association between various measures of obesity and all-cause mortality. Journal of the American Geriatrics Society 57 (11):2077–2084. doi:10.1111/j.1532-5415.2009.02486.x

    Article  PubMed  Google Scholar 

  • Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. The Gerontologist 9 (3):179–186

    Article  CAS  PubMed  Google Scholar 

  • Lee S, Kim TN, Kim SH (2012) Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study. Arthritis and rheumatism 64 (12):3947–3954. doi:10.1002/art.37696

    Article  PubMed  Google Scholar 

  • Levine ME, Crimmins EM (2012) The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning. Obesity (Silver Spring, Md) 20 (10):2101–2106. doi:10.1038/oby.2012.20

    Article  CAS  Google Scholar 

  • Lim S, Kim JH, Yoon JW, Kang SM, Choi SH, Park YJ, Kim KW, Lim JY, Park KS, Jang HC (2010) Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA). Diabetes Care 33 (7):1652–1654. doi:10.2337/dc10-0107

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Linden MA, Pincu Y, Martin SA, Woods JA, Baynard T (2014) Moderate exercise training provides modest protection against adipose tissue inflammatory gene expression in response to high-fat feeding. Physiol Rep 2 (7). doi:10.14814/phy2.12071

    Google Scholar 

  • Look ARG (2014) Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity (Silver Spring, Md) 22 (1):5–13. doi:10.1002/oby.20662

    Article  Google Scholar 

  • Lopez-Jimenez F, Batsis JA, Roger VL, Brekke L, Ting HH, Somers VK (2009) Trends in 10-year predicted risk of cardiovascular disease in the United States, 1976 to 2004. Circulation Cardiovascular quality and outcomes 2 (5):443–450. doi:10.1161/CIRCOUTCOMES.108.847202

    Article  PubMed Central  PubMed  Google Scholar 

  • Lubitz J, Cai L, Kramarow E, Lentzner H (2003) Health, life expectancy, and health care spending among the elderly. The New England journal of medicine 349 (11):1048–1055. doi:10.1056/NEJMsa020614

    Article  CAS  PubMed  Google Scholar 

  • McLean RR, Shardell MD, Alley DE, Cawthon PM, Fragala MS, Harris TB, Kenny AM, Peters KW, Ferrucci L, Guralnik JM, Kritchevsky SB, Kiel DP, Vassileva MT, Xue QL, Perera S, Studenski SA, Dam TT (2014) Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. The journals of gerontology Series A, Biological sciences and medical sciences 69 (5):576–583. doi:10.1093/gerona/glu012

    Article  PubMed Central  PubMed  Google Scholar 

  • Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF (2013) Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA : the journal of the American Medical Association 310 (12):1263–1273. doi:10.1001/jama.2013.277669

    Article  CAS  PubMed  Google Scholar 

  • Morley JE, Anker SD, Evans WJ (2009) Cachexia and aging: an update based on the Fourth International Cachexia Meeting. J Nutr Health Aging 13 (1):47–55

    Article  CAS  PubMed  Google Scholar 

  • Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, Doehner W, Fearon KC, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer ME, Rossi Fanelli F, Schambelan M, Schols AM, Schuster MW, Anker SD, Society for Sarcopenia C, Wasting D (2010) Nutritional recommendations for the management of sarcopenia. Journal of the American Medical Directors Association 11 (6):391–396. doi:10.1016/j.jamda.2010.04.014

    Article  PubMed  Google Scholar 

  • Nair KS, Rizza RA, O’Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ, 3rd, Smith GE, Khosla S, Jensen MD (2006) DHEA in elderly women and DHEA or testosterone in elderly men. The New England journal of medicine 355 (16):1647–1659. doi:10.1056/NEJMoa054629

    Article  CAS  PubMed  Google Scholar 

  • Ogden CL, Carroll MD, Kit BK, Flegal KM (2014) Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA : the journal of the American Medical Association 311 (8):806–814. doi:10.1001/jama.2014.732

    Article  CAS  PubMed  Google Scholar 

  • Okorodudu DO, Jumean MF, Montori VM, Romero-Corral A, Somers VK, Erwin PJ, Lopez-Jimenez F (2010) Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. International journal of obesity 34 (5):791–799. doi:10.1038/ijo.2010.5

    Article  CAS  PubMed  Google Scholar 

  • Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD, investigators Ls (2014) Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA : the journal of the American Medical Association 311 (23):2387–2396. doi:10.1001/jama.2014.5616

    Article  CAS  PubMed  Google Scholar 

  • Physical status: the use and interpretation of anthropometry. Report of a WHO expert committee (1995). World Health Organ Tech Rep Ser, vol 854. World Health Organization,

    Google Scholar 

  • Rabol R, Petersen KF, Dufour S, Flannery C, Shulman GI (2011) Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc Natl Acad Sci U S A 108 (33):13705–13709. doi:10.1073/pnas.1110105108

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D, Million Women Study C (2007) Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ (Clinical research ed) 335 (7630):1134. doi:10.1136/bmj.39367.495995.AE

    Article  Google Scholar 

  • Rolland Y, Lauwers-Cances V, Cristini C, Abellan van Kan G, Janssen I, Morley JE, Vellas B (2009) Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l’OSteoporose) Study. The American journal of clinical nutrition 89 (6):1895–1900. doi:10.3945/ajcn.2008.26950

    Article  CAS  PubMed  Google Scholar 

  • Romero-Corral A, Somers VK, Sierra-Johnson J, Thomas RJ, Collazo-Clavell ML, Korinek J, Allison TG, Batsis JA, Sert-Kuniyoshi FH, Lopez-Jimenez F (2008) Accuracy of body mass index in diagnosing obesity in the adult general population. International journal of obesity 32 (6):959–966. doi:10.1038/ijo.2008.11

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rosemann T, Grol R, Herman K, Wensing M, Szecsenyi J (2008) Association between obesity, quality of life, physical activity and health service utilization in primary care patients with osteoarthritis. The international journal of behavioral nutrition and physical activity 5:4. doi:10.1186/1479-5868-5-4

    Article  PubMed Central  PubMed  Google Scholar 

  • Santilli V, Bernetti A, Mangone M, Paoloni M (2014) Clinical definition of sarcopenia. Clin Cases Miner Bone Metab 11 (3):177–180

    PubMed Central  PubMed  Google Scholar 

  • Sayer AA, Syddall H, Martin H, Patel H, Baylis D, Cooper C (2008) The developmental origins of sarcopenia. J Nutr Health Aging 12 (7):427–432

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schaap LA, Koster A, Visser M (2012) Adiposity, Muscle Mass, and Muscle Strength in Relation to Functional Decline in Older Persons. Epidemiologic reviews. doi:10.1093/epirev/mxs006

    PubMed  Google Scholar 

  • Schrager MA, Metter EJ, Simonsick E, Ble A, Bandinelli S, Lauretani F, Ferrucci L (2007) Sarcopenic obesity and inflammation in the InCHIANTI study. Journal of applied physiology (Bethesda, Md : 1985) 102 (3):919–925. doi:10.1152/japplphysiol.00627.2006

    Article  Google Scholar 

  • Shea MK, Houston DK, Nicklas BJ, Messier SP, Davis CC, Miller ME, Harris TB, Kitzman DW, Kennedy K, Kritchevsky SB (2010) The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study. The journals of gerontology Series A, Biological sciences and medical sciences 65 (5):519–525. doi:10.1093/gerona/glp217

    Article  PubMed  Google Scholar 

  • Sorkin JD, Muller DC, Andres R (1999) Longitudinal change in height of men and women: implications for interpretation of the body mass index: the Baltimore Longitudinal Study of Aging. American journal of epidemiology 150 (9):969–977

    Article  CAS  PubMed  Google Scholar 

  • Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L (2008) Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care 11 (6):693–700. doi:10.1097/MCO.0b013e328312c37d

    Article  PubMed Central  PubMed  Google Scholar 

  • Stephen WC, Janssen I (2009) Sarcopenic-obesity and cardiovascular disease risk in the elderly. J Nutr Health Aging 13 (5):460–466

    Article  CAS  PubMed  Google Scholar 

  • Sternfeld B, Ngo L, Satariano WA, Tager IB (2002) Associations of body composition with physical performance and self-reported functional limitation in elderly men and women. American journal of epidemiology 156 (2):110–121

    Article  PubMed  Google Scholar 

  • Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EB, Nevitt M, Visser M, Kritchevsky S, Badinelli S, Harris T, Newman AB, Cauley J, Ferrucci L, Guralnik J (2011) Gait speed and survival in older adults. JAMA : the journal of the American Medical Association 305 (1):50–58. doi:10.1001/jama.2010.1923

    Article  CAS  PubMed  Google Scholar 

  • Studenski SA, Peters KW, Alley DE, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Fragala MS, Kenny AM, Kiel DP, Kritchevsky SB, Shardell MD, Dam TT, Vassileva MT (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. The journals of gerontology Series A, Biological sciences and medical sciences 69 (5):547–558. doi:10.1093/gerona/glu010

    Article  PubMed Central  PubMed  Google Scholar 

  • Sweeney G (2010) Cardiovascular effects of leptin. Nat Rev Cardiol 7 (1):22–29. doi:10.1038/nrcardio.2009.224

    Article  CAS  PubMed  Google Scholar 

  • Villareal DT, Banks M, Siener C, Sinacore DR, Klein S (2004) Physical frailty and body composition in obese elderly men and women. Obesity research 12 (6):913–920. doi:10.1038/oby.2004.111

    Article  PubMed  Google Scholar 

  • Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K (2011) Weight loss, exercise, or both and physical function in obese older adults. The New England journal of medicine 364 (13):1218–1229. doi:10.1056/NEJMoa1008234

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Warming L, Hassager C, Christiansen C (2002) Changes in bone mineral density with age in men and women: a longitudinal study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 13 (2):105–112. doi:10.1007/s001980200001

    Article  CAS  Google Scholar 

  • Waters DL, Qualls CR, Dorin RI, Veldhuis JD, Baumgartner RN (2008) Altered growth hormone, cortisol, and leptin secretion in healthy elderly persons with sarcopenia and mixed body composition phenotypes. The journals of gerontology Series A, Biological sciences and medical sciences 63 (5):536–541

    Article  PubMed  Google Scholar 

  • Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, Knol DL, Lips P (2007) Vitamin D status predicts physical performance and its decline in older persons. The Journal of clinical endocrinology and metabolism 92 (6):2058–2065. doi:10.1210/jc.2006-1525

    Article  CAS  PubMed  Google Scholar 

  • Williamson DF (1993) Descriptive epidemiology of body weight and weight change in U.S. adults. Annals of internal medicine 119 (7 Pt 2):646–649

    Article  CAS  PubMed  Google Scholar 

  • Wolff JL, Starfield B, Anderson G (2002) Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Archives of internal medicine 162 (20):2269–2276

    Article  PubMed  Google Scholar 

  • Xu L, Freeman G, Cowling BJ, Schooling CM (2013) Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC medicine 11:108. doi:10.1186/1741-7015-11-108

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S (2012) Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. The American journal of clinical nutrition 95 (1):91–100. doi:10.3945/ajcn.111.014779

    Article  CAS  PubMed  Google Scholar 

  • Zizza CA, Herring A, Stevens J, Popkin BM (2002) Obesity affects nursing-care facility admission among whites but not blacks. Obesity research 10 (8):816–823. doi:10.1038/oby.2002.110

    Article  PubMed  Google Scholar 

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Batsis, J.A. (2015). Sarcopenic Obesity. In: Ahima, R. (eds) Metabolic Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-12125-3_38-1

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  1. Latest

    Sarcopenic Obesity
    Published:
    27 July 2023

    DOI: https://doi.org/10.1007/978-3-319-12125-3_38-2

  2. Original

    Sarcopenic Obesity
    Published:
    15 July 2015

    DOI: https://doi.org/10.1007/978-3-319-12125-3_38-1