Definition
Adenosquamous carcinoma (AC) is a deeply infiltrative variant of squamous cell carcinoma where foci of squamous and glandular differentiation coexist.
Clinical Features
Incidence
AC is very rare (only 11 cases have been reported).
Age
Patient age is about 55–60 years.
Sex
Male.
Site
In the majority of the reported cases, AC involves the glans penis commonly extending to involve the urethral meatus, coronal sulcus, and foreskin.
Treatment
Penectomy.
Outcome
They recur locally in 0–25% of the patients. Early and extensive regional lymphnodal diffusion is reported in 43–50% of the cases (Layfield and Liu 2000), but mortality is low, ranging from 0% to 14% (Guimarães et al. 2009).
Microscopy
This unusual neoplasm, probably originating in the penile surface epithelium, has the macroscopic appearance of an exophytic, yellow-grey, firm, granular mass. AC shows a typical biphasic pattern with irregularly shaped, high-grade,...
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References and Further Reading
Cubilla, A. L., Ayala, M. T., Barreto, J. E., Bellasai, J. G., & Nöel, J. C. (1996). Surface adenosquamous carcinoma of the penis. A report of three cases. American Journal of Surgical Pathology, 20(2), 156–160.
Guimarães, G. C., Cunha, I. W., Soares, F. A., Lopes, A., Torres, J., Chaux, A., Velazquez, E. F., Ayala, G., & Cubilla, A. L. (2009). Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. Journal of Urology, 182(2), 528–534.
Layfield, L. J., & Liu, K. (2000). Mucoepidermoid carcinoma arising in the glans penis. Archives of Pathology and Laboratory Medicine, 124(1), 148–151.
Yorita, K., Kuroda, N., Naroda, T., Tamura, M., Ohe, C., Divatia, M., Amin, M. B., Cubilla, A. L., Kazakov, D. V., Hes, O., Michal, M., & Michal, M. (2018). Penile warty mucoepidermoid carcinoma with features of stratified mucin-producing intra-epithelial lesion and invasive stratified mucin-producing carcinoma. Histopathology, 72(5), 867–873.
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Colecchia, M., Bertolotti, A. (2019). Penile Adenosquamous Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4877-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4877-1
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