Synonyms
Hyalinizing trabecular adenoma; Hyalinizing trabecular neoplasm
A remarkable, erudite review of the terminology and of the earlier descriptions of this lesion has been published in 2008 (Carney 2008).
Clinical Features
Incidence
HTT is a rare tumor, usually incidentally found during a routine physical examination.
Age
It usually occurs between the second and seventh decade of life, but the mean age of the patients is 50 (Papotti and Volante 2017)
Sex
HTT has a striking female predominance (female-to-male ratio, 6:1).
Site
A slight prevalence in the right lobe has been recorded (Carney et al. 2008).
Treatment
HTT should be treated conservatively.
Outcome
HTT is considered a benign tumor, although rare cases of invasive HTT have...
References and Further Reading
Carney, J. A. (2008). Hyalinizing trabecular tumors of the thyroid gland: Quadruply described but not by the discoverer. The American Journal of Surgical Pathology, 32, 622–634.52.
Carney, J. A., Ryan, J., & Goellner, J. R. (1987). Hyalinizing trabecular adenoma of the thyroid gland. The American Journal of Surgical Pathology, 11, 583–591.
Carney, J. A., Hirokawa, M., Lloyd, R. V., Papotti, M., & Sebo, T. J. (2008). Hyalinizing trabecular tumors of the thyroid gland are almost all benign. The American Journal of Surgical Pathology, 32, 1877–1889.
Casey, M. B., Sebo, T. J., & Carney, J. A. (2004). Hyalinizing trabecular adenoma of the thyroid gland: Cytologic features in 29 cases. The American Journal of Surgical Pathology, 28, 859–867.
Cheung, C. C., Boerner, S. L., MacMillan, C. M., Ramyar, L., & Asa, S. L. (2000). Hyalinizing trabecular tumor of the thyroid: A variant of papillary carcinoma proved by molecular genetics. The American Journal of Surgical Pathology, 24, 1622–1626.
Dell’Aquila, M., Gravina, C., Cocomazzi, A., Capodimonti, S., Musarra, T., Sfregola, S., Fiorentino, V., Revelli, L., Martini, M., Fadda, G., Pantanowitz, L., Larocca, L. M., & Rossi, E. D. (2019). A large series of hyalinizing trabecular tumors: Cytomorphology and ancillary techniques on fine needle aspiration. Cancer Cytopathology. https://doi.org/10.1002/cncy.22139.
González-Cámpora, R., Fuentes-Vaamonde, E., Hevia-Vázquez, A., Otal-Salaverri, C., Villar-Rodriguez, J. L., & Galera-Davidson, H. (1998). Hyalinizing trabecular carcinoma of the thyroid gland: Report of two cases of follicular cell thyroid carcinoma with hyalinizing trabecular pattern. Ultrastructural Pathology, 22, 39–46.
Leonardo, E., Volante, M., Barbareschi, M., Cavazza, A., Dei Tos, A. P., Bussolati, G., & Papotti, M. (2007). Cell membrane reactivity of MIB1 antibody to Ki67 in human tumors: Fact or artifact? Applied Immunohistochemistry & Molecular Morphology, 15, 220–223.
Marchiò, C., Da Cruz, P. A., Gularte-Merida, R., Basili, T., Brandes, A., da Silva, E. M., Silveira, C., Ferrando, L., Metovic, J., Maletta, F., Annaratone, L., Pareja, F., Rubin, B. P., Hoschar, A. P., De Rosa, G., La Rosa, S., Bongiovanni, M., Purgina, B., Piana, S., Volante, M., Weigelt, B., Reis-Filho, J. S., & Papotti, M. (2019). PAX8-GLIS3 gene fusion is a pathognomonic genetic alteration of hyalinizing trabecular tumors of the thyroid. Modern Pathology, 32, 1734–1743.
McCluggage, W. G., & Sloan, J. M. (1996). Hyalinizing trabecular carcinoma of thyroid gland. Histopathology, 28, 357–362.
Molberg, K., & Albores-Saavedra, J. (1994). Hyalinizing trabecular carcinoma of the thyroid gland. Human Pathology, 25, 192–197.
Nikiforova, M. N., Nikitski, A. V., Panebianco, F., Kaya, C., Yip, L., Williams, M., Chiosea, S. I., Seethala, R. R., Roy, S., Condello, V., Santana-Santos, L., Wald, A. I., Carty, S. E., Ferris, R. L., El-Naggar, A. K., & Nikiforov, Y. E. (2019). GLIS rearrangement is a genomic hallmark of hyalinizing trabecular tumor of the thyroid gland. Thyroid, 29, 161–173.
Papotti, M., & Volante, M. (2017). Hyalinizing trabecular tumor. In R. V. Lloyd, R. Y. Osamura, G. Klöppel, & J. Rosai (Eds.), WHO classification of tumors of endocrine organs (pp. 73–74). Lyon: IARC.
Papotti, M., Volante, M., Giuliano, A., Fassina, A., Fusco, A., Bussolati, G., Santoro, M., & Chiappetta, G. (2000). Ret/PTC activation in hyalinizing trabecular tumors of the thyroid. The American Journal of Surgical Pathology, 24, 1615–1622.
Saglietti, C., Piana, S., La Rosa, S., & Bongiovanni, M. (2017). Hyalinizing trabecular tumour of the thyroid: Fine-needle aspiration cytological diagnosis and correlation with histology. Journal of Clinical Pathology, 70, 641–647.
Salvatore, G., Chiappetta, G., Nikiforov, Y. E., Decaussin-Petrucci, M., Fusco, A., Carney, J. A., & Santoro, M. (2005). Molecular profile of hyalinizing trabecular tumours of the thyroid: High prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations. European Journal of Cancer, 41, 816–821.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this entry
Cite this entry
Piana, S. (2020). Hyalinizing Trabecular Tumor (HTT). In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5261-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-28845-1_5261-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28845-1
Online ISBN: 978-3-319-28845-1
eBook Packages: Springer Reference MedicineReference Module Medicine