Synonyms
Definition
A benign tumor within the dermis or subcutis with prominent vascularity and perivascular myoid differentiation. It lies on a morphological continuum with myofibroma and glomangioma (Dray et al. 2006).
Clinical Features
Incidence
Myopericytoma is rare.
Age
Myopericytoma usually affects adults (Granter et al. 1998). However, it may occur at any age.
Sex
There is a male predominance (Granter et al. 1998).
Site
Myopericytomas usually develop within the dermis and subcutis, rarely in the deep soft tissues. Most affect distal extremities, followed by proximal extremities, neck, trunk, and seldom oral cavity (Granter et al. 1998).
Treatment
Surgery is the treatment. Recurrence is very rare, even in case of marginal or incomplete surgical excision.
Outcome
Myopericytoma is a benign, occasionally recurrent tumor (Mentzel et al. 2006). The occurrence of additional new myopericytomas in the same body region has been reported. Exceptionally rare...
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References and Further Reading
Dahlén, A., Fletcher, C. D., Mertens, F., Fletcher, J. A., Perez-Atayde, A. R., Hicks, M. J., … & Mandahl, N. (2004). Activation of the GLI oncogene through fusion with the β-actin gene (ACTB) in a group of distinctive pericytic neoplasms: Pericytoma with t (7; 12). The American Journal of Pathology, 164(5), 1645–1653.
Dray, M. S., McCarthy, S. W., Palmer, A. A., Bonar, S. F., Stalley, P. D., Marjoniemi, V., … & Scolyer, R. A. (2006). Myopericytoma: A unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. Journal of Clinical Pathology, 59(1), 67–73.
Fisher, C. (2013). Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor. Seminars in Diagnostic Pathology, 30(1), 73–84.
Granter, S. R., Badizadegan, K., & Fletcher, C. D. (1998). Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: A spectrum of tumors showing perivascular myoid differentiation. The American Journal of Surgical Pathology, 22(5), 513–525.
McMenamin, M. E., & Fletcher, C. D. M. (2002). Malignant myopericytoma: Expanding the spectrum of tumours with myopericytic differentiation. Histopathology, 41(5), 450–460.
Mentzel, T., Dei Tos, A. P., Sapi, Z., & Kutzner, H. (2006). Myopericytoma of skin and soft tissues: Clinicopathologic and immunohistochemical study of 54 cases. The American Journal of Surgical Pathology, 30(1), 104–113.
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Cappellesso, R. (2020). Myopericytoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5435-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5435-1
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