Synonyms
Adenosquamous carcinoma; Mucoepidermoid tumor; Squamous cell carcinoma with mucin-secreting component
Definition
Mucoepidermoid carcinoma is a malignant epithelial glandular tumor characterized by the presence, in variable proportions, of mucin-producing, intermediate, and squamoid cells that can undergo columnar, clear, and oncocytic change.
Clinical Features
Incidence
Mucoepidermoid carcinoma is a very rare esophageal neoplasm, accounting for less than 1% of malignant neoplasms.
Age
Most cases of mucoepidermoid carcinoma of the esophagus are reported in patients in their sixth to seventh decades.
Sex
Most cases occur in men, with an M/F ratio between 2:1 and 3:1.
Site
Most mucoepidermoid carcinomas arise in the lower two-thirds of the esophagus.
Treatment
Surgery is the treatment of choice for mucoepidermoid carcinoma, following the guidelines for the treatment of esophageal squamous cell carcinoma. Positive margins and high histological grade warrant postoperative...
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References and Further Reading
Chen, S., Chen, Y., Yang, J., Yang, W., Weng, H., Li, H., & Liu, D. (2011). Primary mucoepidermoid carcinoma of the esophagus. Journal of Thoracic Oncology, 6, 1426–1431.
Huang, Q., Shi, J., Sun, Q., Fan, X., Feng, A., Wu, H., Zhou, Q., Yu, C., Mashimo, H., & Lauwers, G. Y. (2012). Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare. Human Pathology.http://dx.doi.org/10.1016/j.humpath.2012.02.018
Lieberman, M. D., Franceschi, D., Marsan, B., & Burt, M. (1994). Esophageal carcinoma. The unusual variants. The Journal of Thoracic and Cardiovascular Surgery, 108, 1138–1146.
Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A. B., Komiya, T., O’Neil, K., Stover, K., El-Naggar, A., Griffin, J. D., Kirsh, I. R., & Kaye, F. J. (2003). t(11:19)(q21:p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a NOTCH signalling pathway. Nature Genetics, 33, 208–213.
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Fonseca, I. (2017). Mucoepidermoid Carcinoma, Esophageal. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1657
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1657
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