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Fish as a Model for Research in Space

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Handbook of Space Pharmaceuticals

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Abstract

A new facility for rearing small fish was established in the International Space Station (ISS) in 2012 and the experiments employing medaka fish and zebrafish were performed for studies of revealing the mechanism of bone loss and muscle atrophy under microgravity. Firstly, we introduce all experiments withsmall fish performed in the ISS, and then mainly report recent experiments for medaka fish. Space flight with low gravity shows decrease in bone mineral density. To identify the mechanism of this low density, unique experiments on medaka fish were performed twice at the ISS. One was a long-term experiment for the analysis of bone growth, which revealed a decrease in the mineral density. Another was a short-term experiment for live imaging of medaka transgenic lines followed by transcriptome analyses, which revealed increased expressions of five genes.

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Acknowledgments

This work was supported by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (16K15778 and 16H01635).

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Authors and Affiliations

  1. Department of Pharmacology, School of Dentistry, Showa University, Tokyo, Japan

    Masahiro Chatani & Akira Kudo

  2. International Frontier, Tokyo Institute of Technology, Tokyo, Japan

    Akira Kudo

Authors
  1. Masahiro Chatani
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  2. Akira Kudo
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Corresponding author

Correspondence to Akira Kudo .

Editor information

Editors and Affiliations

  1. Health College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant Pathak

  2. InnovaSpace Ltd, London, UK

    Marlise Araújo dos Santos

  3. BioServe Space Technologies, University of Colorado, Boulder, CO, USA

    Luis Zea

Section Editor information

  1. Assistant Research Professor, BioServe Space Technologies, University of Colorado, Boulder, Colorado, USA

    Luis Zea Ph.D

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Chatani, M., Kudo, A. (2019). Fish as a Model for Research in Space. In: Pathak, Y., Araújo dos Santos, M., Zea, L. (eds) Handbook of Space Pharmaceuticals. Springer, Cham. https://doi.org/10.1007/978-3-319-50909-9_5-1

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  • DOI: https://doi.org/10.1007/978-3-319-50909-9_5-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-50909-9

  • Online ISBN: 978-3-319-50909-9

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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