Synonyms
Behavioral variant frontotemporal dementia; Dementia of frontal lobe type; Frontal lobe dementia
Short Description or Definition
The term “Pick’s disease” has been used to describe a neuropathological entity and/or a clinical syndrome. Pathologists use this term on the basis of the histologic criteria of argyrophilic inclusions (Pick bodies) and ballooned neurons (Pick cells). As a clinical syndrome, Pick’s disease is used to describe progressive alterations in personality and behavior (e.g., frontotemporal dementia [FTD]), and/or language (e.g., progressive aphasia).
Categorization
Developments in molecular pathology have led to the classification of Pick’s disease as a tauopathy, defined neuropathologically by the presence of tau immunoreactive Pick bodies (Lee et al. 2001). Compared to other tauopathies (e.g., progressive supranuclear palsy [PSP] and corticobasal degeneration [CBD]), the distribution of pathology is more likely to be cortical than subcortical, and Pick...
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Musil, S., Johnson, N. (2018). Pick’s Disease. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_508
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DOI: https://doi.org/10.1007/978-3-319-57111-9_508
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