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Diabetes in the Arab World

  • Living reference work entry
  • First Online:
Handbook of Healthcare in the Arab World

Abstract

The prevalence of diabetes in the Arab world increased greatly during the past two decades, largely due to adaptation to Western lifestyles and poor dietary choices. Diabetes in the Arab world is estimated to double in 2035. Hereditary risk factors play a key role in the uncontrolled prevalence of diabetes in the Middle East. However, obesity and a lack of exercise cannot be ignored as factors in the swift rise of diabetes in the Arab world. Half of the patients suffering from diabetes are unaware of their condition and are at great risk of diabetic complications; such patients are a large component of the high rates of morbidity and mortality in diabetic patients in the Arab world. The majority of costs associated with diabetes relate to treatments of diabetic complications. Therefore, early treatment in diabetes is important both for health as well as in reducing long-term costs. This chapter discusses the chronic complications of diabetes by dividing them into microvascular and macrovascular diseases, where microvascular complications have a higher prevalence. Microvascular complications involve nephropathy, neuropathy, and retinopathy, while macrovascular complications include stroke, cardiovascular diseases, and peripheral artery diseases. There is an urgent need to fight the spread of diabetes in the Arab world considering the epidemic of diabetes in the region.

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References

  • Abdullah MA (2005) Epidemiology of type I diabetes mellitus among Arab children. Saudi Med J 26(6):911–917

    PubMed  Google Scholar 

  • Abuyassin B, Laher I (2016) Diabetes epidemic sweeping the Arab world. World J Diabetes 7(8):165–174

    Google Scholar 

  • Adamo M, Codella R, Casiraghi F, Ferrulli A, Macrì C, Bazzigaluppi E, Terruzzi I, Inverardi L, Ricordi C, Luzi L (2017) Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls. Cell Transplant 26(1):23–32

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Afshin A, Micha R, Khatibzadeh S et al (2015) The impact of dietary habits and metabolic risk factors on cardiovascular and diabetes mortality in countries of the Middle East and North Africa in 2010: a comparative risk assessment analysis. BMJ Open 5:e006385

    Article  PubMed  PubMed Central  Google Scholar 

  • Alaboud AF, Tourkmani AM, Alharbi TJ, Alobikan AH, Abdelhay O, Al Batal SM, Alkashan HI, Mohammed UY (2016) Microvascular and macrovascular complications of type 2 diabetic mellitus in Central, Kingdom of Saudi Arabia. Saudi Med J 37(12):1408–1411

    Article  PubMed  PubMed Central  Google Scholar 

  • Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120(16):1640–1645

    Article  CAS  PubMed  Google Scholar 

  • Alrawahi AH, Rizvi SG, Al-Riyami D, Al-Anqoodi Z (2012) Prevalence and risk factors of diabetic nephropathy in omani type 2 diabetics in Al-dakhiliyah region. Oman Med J 27:212–216

    Google Scholar 

  • Al-Adsani AM (2007) Risk factors for diabetic retinopathy in Kuwaiti type 2 diabetic patients. Saudi Med J 28:579–583

    Google Scholar 

  • Al-Akily SA, Bamashmus MA, Gunaid AA (2011) Causes of visual impairment and blindness among Yemenis with diabetes: a hospital-based study. East Mediterr Health J 17:831–837

    Google Scholar 

  • Al-Khawlani A, Atef ZA, Al-Ansi A (2010) Macrovascular complications and their associated risk factors in type 2 diabetic patients in Sana’ a city, Yemen. East Mediterr Health J 16:851–858

    Google Scholar 

  • Al-Lawati JA, N Barakat M, Al-Zakwani I, Elsayed MK, AlMaskari M, M Al-Lawati N, Mohammed AJ (2012) Control of risk factors for cardiovascular disease among adults with previously diagnosed type 2 diabetes mellitus: a descriptive study from a middle eastern arab population. Open Cardiovasc Med J 6:133–140

    Google Scholar 

  • Al-Mahroos F, Al-Roomi K (2007) Diabetic neuropathy, foot ulceration, peripheral vascular disease and potential risk factors among patients with diabetes in Bahrain: a nationwide primary care diabetes clinic-based study. Ann Saudi Med 27:25–31

    Google Scholar 

  • Al-Maskari F, El-Sadig M (2007) Prevalence of diabetic retinopathy in the United Arab Emirates: a cross-sectional survey. BMC Ophthalmol 7:11

    Google Scholar 

  • Al-Maskari AY, Al-Maskari MY, Al-Sudairy S (2011) Oral manifestations and complications of diabetes mellitus: a review. Sultan Qaboos Univ Med J 11(2):179–186

    PubMed  PubMed Central  Google Scholar 

  • Al-Rubeaan K, Al Derwish M, Ouizi S, Youssef AM, Subhani SN, Ibrahim HM, Alamri BN (2015) Diabetic foot complications and their risk factors from a large retrospective cohort study. PloS one, 10(5)

    Google Scholar 

  • Al-Till MI, Al-Bdour MD, Ajlouni KM (2005) Prevalence of blindness and visual impairment among Jordanian diabetics. Eur J Ophthalmol 15:62–68

    Google Scholar 

  • Almetwazi M, Alwhaibi M, Balkhi B, Almohaini H, Alturki H, Alhawassi T, Ata S, AlQahtani N, Mahmoud M, Alshammari T (2019) Factors associated with glycemic control in type 2 diabetic patients in Saudi Arabia. Saudi Phram J 27(3):384–388

    Article  Google Scholar 

  • American Diabetes Association (2003) Peripheral arterial disease in people with diabetes. Diabetes care 26(12):3333–3341

    Google Scholar 

  • American Diabetes Association (2012a) Executive summary: standards of medical care in diabetes – 2012. Diabetes Care 35(Suppl 1):S4–S10

    Google Scholar 

  • American Diabetes Association (2012b) Standards of medical care in diabetes – 2012. Diabetes Care 35(Suppl 1):S11–S63

    Google Scholar 

  • Assaad-Khalil SH, Zaki A, Abdel Rehim A, Megallaa MH, Gaber N, Gamal H, Rohoma KH (2015) Prevalence of diabetic foot disorders and related risk factors among Egyptian subjects with diabetes. Prim Care Diabetes 9:297–303

    Google Scholar 

  • Awad HH, McManus DD, Anderson FA Jr, Gore JM, Goldberg RJ (2013) Young patients hospitalized with an acute coronary syndrome. Coron Artery Dis 24(1):54–60

    Article  PubMed  Google Scholar 

  • Bamashmus MA, Gunaid AA, Khandekar RB (2009) Diabetic retinopathy, visual impairment and ocular status among patients with diabetes mellitus in Yemen: a hospitalbased study. Indian J Ophthalmol 57:293–298

    Google Scholar 

  • Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H (2015) Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimers Dement 11(6):718–726

    Article  PubMed  Google Scholar 

  • Beckman JA, Creager MA (2016) Vascular complications of diabetes. Circ Res 118(11):1771–1785

    Article  CAS  PubMed  Google Scholar 

  • Behnam-Rassouli M, Ghayour MB, Ghayour N (2010) Microvascular complications of diabetes. J Biol Sci 10(5):411–423

    Article  Google Scholar 

  • Bener A, Al-Laftah F, Al-Hamaq AO, Daghash M, Abdullatef WK (2014) A study of diabetes complications in an endogamous population: an emerging public health burden. Diabetes Metab Syndr 8:108–114

    Google Scholar 

  • Bierhaus A, Humpert PM, Morcos M, Wendt T, Chavakis T, Arnold B, Stern DM, Nawroth PP (2005) Understanding RAGE, the receptor for advanced glycation end products. J Mol Med 83(11):876–886

    Article  CAS  PubMed  Google Scholar 

  • Boehme AK, Esenwa C, Elkind MS (2017) Stroke risk factors, genetics, and prevention. Circ Res 120(3):472–495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Boles A, Kandimalla R, Reddy PH (2017) Dynamics of diabetes and obesity: epidemiological perspective. Biochim Biophys Acta 1863(5):1026–1036

    Article  CAS  PubMed Central  Google Scholar 

  • Bondi C, Barra F, Ferrero S (2018) Epidemiology and risk factors. In: Endometrial cancer: risk factors, management and prognosis. Nova Science Publishers, New York, pp 1–24

    Google Scholar 

  • Bornfeldt KE, Tabas I (2011) Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab 14(5):575–585

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bosevski M (2012) Peripheral arterial disease and diabetes. Prilozi 33(1):65–78

    CAS  PubMed  Google Scholar 

  • Boulton AJ (2005) Management of diabetic peripheral neuropathy. Clin Diabetes 23(1):9–15

    Article  Google Scholar 

  • Boutayeb A, Lamlili M, Boutayeb W, Maamri A, Ziyyat A, Ramdani N (2012) The rise of diabetes prevalence in the Arab region. Open J Epidemiol 2(2):55–60

    Article  Google Scholar 

  • Brenta G (2010) Diabetes and thyroid disorders. Br J Diabetes Vasc Dis 10(4):172–177

    Article  CAS  Google Scholar 

  • Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414(6865):813–820

    Article  CAS  PubMed  Google Scholar 

  • Canivell S, Gomis R (2014) Diagnosis and classification of autoimmune diabetes mellitus. Autoimmun Rev 13(4–5):403–407

    Article  CAS  PubMed  Google Scholar 

  • Cannon A, Handelsman Y, Heile M, Shannon M (2018) Burden of illness in type 2 diabetes mellitus. J Manag Care Spec Pharm 24(9-a Suppl):S5–S13

    PubMed  Google Scholar 

  • Carracher AM, Marathe PH, Close KL (2018) International Diabetes Federation 2017. J Diabetes 10(5):353–356

    Google Scholar 

  • Chatterjee A, Gerdes MW, Martinez SG (2020) Identification of risk factors associated with obesity and overweight – a machine learning overview. Sensors 20(9):2734

    Article  PubMed Central  Google Scholar 

  • Chawla A, Chawla R, Jaggi S (2016) Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian J Endorinol Metab 20(4):546–551

    Article  CAS  Google Scholar 

  • Cirilli I, Silvestri S, Marcheggiani F, Olivieri F, Galeazzi R, Antonicelli R, Recchioni R, Marcheselli F, Bacchetti T, Tiano L, Orlando P (2019) Three months monitored metabolic fitness modulates cardiovascular risk factors in diabetic patients. Diabetes Metab J 43(6):893–897

    Article  PubMed  PubMed Central  Google Scholar 

  • Clark N, Sheehan P, Edmonds M, Januzzi JL, Regensteiner J, Sanders L, Sykes M, Attinger CE, Beckman J, Criqui M, Froelich JB (2003) Peripheral arterial disease in people with diabetes. Diabetes Care 26(12):3333–3341

    Article  Google Scholar 

  • Courtney CH, Olefsky JM (2007) Insulin resistance. In: Mechanisms of insulin action. Springer, New York

    Google Scholar 

  • de Vegt F, Dekker J, Ruhé H et al (1999) Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia 42:926–931

    Article  PubMed  Google Scholar 

  • Deckelbaum RJ, Williams CL (2001) Childhood obesity: the health issues. Obes Res 9(Suppl):239S–243S

    Article  PubMed  Google Scholar 

  • Deshpande AD, Harris-Hayes M, Schootman M (2008) Epidemiology of diabetes and diabetes-related complications. Phys Ther 88(11):1254–1264

    Article  PubMed  PubMed Central  Google Scholar 

  • Diabetes Epidemiology Research International Study Group (1990) Childhood diabetes in Arab countries. Bull World Health Organ 68(2):231–236

    Google Scholar 

  • Edwards JL, Vincent AM, Cheng HT, Feldman EL (2008) Diabetic neuropathy: mechanisms to management. Pharmacol Ther 120(1):1–34

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Elshafei M, Gamra H, Khandekar R, Al Hashimi M, Pai A, Ahmed MF (2011) Prevalence and determinants of diabetic retinopathy among persons ≥ 40 years of age with diabetes in Qatar: a communitybased survey. Eur J Ophthalmol 21:39–47

    Google Scholar 

  • Emerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S et al (2010) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 375(9733):2215–2222

    Article  CAS  Google Scholar 

  • Forbes JM, Cooper ME (2013) Mechanisms of diabetic complications. Physiol Rev 93(1):137–188

    Article  CAS  PubMed  Google Scholar 

  • Galtier F (2010) Definition, epidemiology, risk factors. Diabetes Metab 36(6 Pt 2):628–651

    Article  CAS  PubMed  Google Scholar 

  • Gowan J, Roller L (2013) Disease state management: diabetes complications. Aust J Pharm 94(1122):62

    Google Scholar 

  • Gunaid AA, El Khally FM, Hassan NA, Mukhtar el D (1997) Demographic and clinical features of diabetes mellitus in 1095 Yemeni patients. Ann Saudi Med 17:402–409

    Google Scholar 

  • Hajar S, Al Hazmi A, Wasli M, Mousa A, Rabiu M (2015) Prevalence Abuyassin B et al. T2DM in the Arab world. Saudi Med J 36:449–455

    Google Scholar 

  • Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW (2019) Global trends in diabetes complications: a review of current evidence. Diabetologia 62(1):3–16

    Article  PubMed  Google Scholar 

  • Haslam D, Sattar N, Lean M (2006) Obesity – time to wake up. BMJ 333(7569):640–642

    Article  PubMed  PubMed Central  Google Scholar 

  • Herman WH, Aubert RE, Engelgau MM, Thompson TJ, Ali MA, Sous ES, Hegazy M, Badran A, Kenny SJ, Gunter EW, Malarcher AM, Brechner RJ, Wetterhall SF, DeStefano F, Smith PJ, Habib M, abd el Shakour S, Ibrahim AS, el Behairy EM (1998) Diabetes mellitus in Egypt: glycaemic control and microvascular and neuropathic complications. Diabet Med 15:1045–1051

    Google Scholar 

  • Hegazi R, El-Gamal M, Abdel-Hady N, Hamdy O (2015) Epidemiology of and risk factors for type 2 diabetes in Egypt. Ann Glob Health 81(6):814–820

    Article  PubMed  Google Scholar 

  • Hoseini A, Mirzapour A, Bijani A, Shirzad A (2017) Salivary flow rate and xerostomia in patients with type I and II diabetes mellitus. Electron Physician 9(9):5244–5249. https://doi.org/10.19082/5244

    Article  PubMed  PubMed Central  Google Scholar 

  • Huang D, Refaat M, Mohammedi K, Jayyousi A, Al Suwaidi J, Abi Khalil C (2017) Macrovascular complications in patients with diabetes and prediabetes. Biomed Res Int 2017:7839101

    Article  PubMed  PubMed Central  Google Scholar 

  • Hurt RT, Kulisek C, Buchanan LA, McClave SA (2010) The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists. Gastroenterol Hepatol 6(12):780–792

    Google Scholar 

  • International Diabetes Federation (2013) Short communication 101(3):343–351

    Google Scholar 

  • International Diabetes Federation (2017) IDF diabetes atlas, 8th edn. International Diabetes Federation, Brussels

    Google Scholar 

  • International Diabetes Federation (2019) IDF diabetes atlas, 9th edn. International Diabetes Federation, Brussels

    Google Scholar 

  • Jaber LA, Brown MB, Hammad A, Nowak SN, Zhu Q, Ghafoor A, Herman WH (2003) Epidemiology of diabetes among Arab Americans. Diabetes Care 26(2):308–313

    Article  PubMed  Google Scholar 

  • Jbour AS, Jarrah NS, Radaideh AM, Shegem NS, Bader IM, Batieha AM, Ajlouni KM (2003) Prevalence and predictors of diabetic

    Google Scholar 

  • Jovanovič L, Liang Y, Weng W, Hamilton M, Chen L, Wintfeld N (2015) Trends in the incidence of diabetes, its clinical sequelae, and associated costs in pregnancy. Diabetes Metab Res Rev 31(7):707–716

    Article  PubMed  PubMed Central  Google Scholar 

  • Juster-Switlyk K, Smith AG (2016) Updates in diabetic peripheral neuropathy. F1000Res 5:F1000 Faculty Rev-738

    Google Scholar 

  • Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106(4):473–481

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kannel WB, McGee DL (1979) Diabetes and cardiovascular disease: the Framingham study. JAMA 241(19):2035–2038

    Article  CAS  PubMed  Google Scholar 

  • Kannel WB, Hjortland M, Castelli WP (1974) Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol 34(1):29–34

    Article  CAS  PubMed  Google Scholar 

  • Kastorini CM, Panagiotakos DB (2009) Dietary patterns and prevention of type 2 diabetes: from research to clinical practice; a systematic review. Curr Diabetes Rev 5(4):221–227

    Article  CAS  PubMed  Google Scholar 

  • Khader YS, Dauod AS, El-Qaderi SS, Alkafajei A, Batayha WQ (2006) Periodontal status of diabetics compared with nondiabetics: a meta-analysis. J Diabetes Complicat 20:59–68

    Article  Google Scholar 

  • Khandekar R, Al Lawatii J, Mohammed AJ, Al Raisi A (2003) Diabetic retinopathy in Oman: a hospital based study. Br J Ophthalmol 87:1061–1064

    Google Scholar 

  • King KD, Jones JD, Warthen J (2005) Microvascular and macrovascular complications of diabetes mellitus. Am J Pharm Educ 69(5):1–10

    Article  Google Scholar 

  • Kontogianni MD, Liatis S, Grammatikou S, Perrea D, Katsilambros N, Makrilakis K (2012) Changes in dietary habits and their association with metabolic markers after a non-intensive, community-based lifestyle intervention to prevent type 2 diabetes, in Greece. The DEPLAN study. Diabetes Res Clin Pract 95(2):207–214

    Article  PubMed  Google Scholar 

  • Kowluru RA, Chan PS (2007) Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007:43603

    Article  PubMed  PubMed Central  Google Scholar 

  • Laakso M, Kuusisto J (2014) Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol 10(5):293–302

    Article  CAS  PubMed  Google Scholar 

  • Lamster IB, Lalla E, Borgnakke WS, Taylor GW (2008) The relationship between oral health and diabetes mellitus. J Am Dent Assoc 139(Suppl):19S–24S

    Article  PubMed  Google Scholar 

  • Latti BR, Kalburge JV, Birajdar SB, Latti RG (2018) Evaluation of relationship between dental caries, diabetes mellitus and oral microbiota in diabetics. J Oral Maxillofac Pathol 22(2):282

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee R, Wong TY, Sabanayagam C (2015) Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis 2(1):17

    Article  Google Scholar 

  • Lester FT (2019) Diabetes mellitus. In: The ecology of health and disease in Ethiopia. Routledge, London

    Google Scholar 

  • Lim AKH (2014) Diabetic nephropathy – complications and treatment. Int J Nephrol Renov Dis 7(1):361–381

    Article  Google Scholar 

  • Luitse MJ, Biessels GJ, Rutten GE, Kappelle LJ (2012) Diabetes, hyperglycaemia, and acute ischaemic stroke. Lancet Neurol 11(3):261–271

    Article  PubMed  Google Scholar 

  • MacKy TA, Khater N, Al-Zamil MA, El Fishawy H, Soliman MM (2011) Epidemiology of diabetic retinopathy in Egypt: a hospital-based study. Ophthalmic Res 45:73–78

    Google Scholar 

  • Marín-Peñalver JJ, Martín-Timón I, Sevillano-Collantes C, del Cañizo-Gómez FJ (2016) Update on the treatment of type 2 diabetes mellitus. World J Diabetes 7(17):354–395

    Article  PubMed  PubMed Central  Google Scholar 

  • Marso SP, Hiatt WR (2006) Peripheral arterial disease in patients with diabetes. J Am Coll Cardiol 47(5):921–929

    Article  PubMed  Google Scholar 

  • Méndez JD, Xie J, Aguilar-Hernández M, Méndez-Valenzuela V (2010) Trends in advanced glycation end products research in diabetes mellitus and its complications. Mol Cell Biochem 341(1–2):33–41

    Article  PubMed  CAS  Google Scholar 

  • Meo SA, Usmani AM, Qalbani E (2017) Prevalence of type 2 diabetes in the Arab world: impact of GDP and energy consumption. Eur Rev Med Pharmacol Sci 21(6):1303–1312

    CAS  PubMed  Google Scholar 

  • Mian RI, Rashidi FF, Alshammary TM, Al Zubaidi S, Al Shammary F, Siddiqui AA, Amin J, Khan RS (2020) Oral health-related knowledge and assessment of oral health status of diabetic patients attending dental clinics at College of Dentistry, Hail, Saudi Arabia. J Contemp Dent Pract 21(1):78–82

    Article  PubMed  Google Scholar 

  • Micha R, Wallace SK, Mozaffarian D (2010) Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis. Circulation 121(1):2271–2283

    Article  PubMed  PubMed Central  Google Scholar 

  • Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289(1):76–79

    Article  PubMed  Google Scholar 

  • Mokdad AH, Jaber S, Aziz MI, AlBuhairan F, AlGhaithi A, AlHamad NM, Al-Hooti SN, Al-Jasari A, AlMazroa MA, AlQasmi AM, Alsowaidi S (2014) The state of health in the Arab world, 1990–2010: an analysis of the burden of diseases, injuries, and risk factors. Lancet 383(9914):309–320

    Article  PubMed  Google Scholar 

  • Müller-Nordhorn J, Willich SN (2016) Coronary heart disease. In: International encyclopedia of public health. Elsevier, Amsterdam

    Google Scholar 

  • Napoli N, Chandran M, Pierroz DD, Abrahamsen B, Schwartz AV, Ferrari SL (2017) Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol 13(4):208–219

    Article  CAS  PubMed  Google Scholar 

  • Nentwich MM, Ulbig MW (2015) Diabetic retinopathy – ocular complications of diabetes mellitus. World J Diabetes 6(3):489–499

    Article  PubMed  PubMed Central  Google Scholar 

  • Oggioni C, Lara J, Wells JC, Soroka K, Siervo M (2014) Shifts in population dietary patterns and physical inactivity as determinants of global trends in the prevalence of diabetes: an ecological analysis. Nutr Metab Cardiovasc Dis 24(10):1105–1111

    Article  CAS  PubMed  Google Scholar 

  • Okeda T (1996) Diabetes and atherosclerosis. Rinsho Byori 44(11):1027–1030

    CAS  PubMed  Google Scholar 

  • Perera ND, Bandara KM, Ranasinghe IR, Gunatilake SB (2015) Comparison of risk factors, severity and outcome between lacunar and non-lacunar stroke in a tertiary care center in Sri Lanka: a descriptive study. Ceylon Med J 60(3):103–106

    Article  CAS  PubMed  Google Scholar 

  • Prenner SB, Chirinos JA (2015) Arterial stiffness in diabetes mellitus. Atherosclerosis 238(2):370–379

    Article  CAS  PubMed  Google Scholar 

  • Preshaw PM, Taylor JJ (2011) How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? J Clin Periodontol 38(Suppl 11):60–84

    Article  PubMed  Google Scholar 

  • Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R (2012) Periodontitis and diabetes: a two-way relationship. Diabetologia 55(1):21–31

    Article  CAS  PubMed  Google Scholar 

  • Rabiu MM, Al Bdour MD, Abu Ameerh MA, Jadoon MZ (2015) Prevalence of blindness and diabetic retinopathy in northern Jordan. Eur J Ophthalmol 25:320–327

    Google Scholar 

  • Rahim HF, Sibai A, Khader Y, Hwalla N, Fadhil I, Alsiyabi H, Mataria A, Mendis S, Mokdad AH, Husseini A (2014) Non-communicable diseases in the Arab world. Lancet 383(9914):356–367

    Article  PubMed  Google Scholar 

  • Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37(12):1595–1607

    Article  CAS  PubMed  Google Scholar 

  • Rogers LC, Malik RA (2010) Painful diabetic neuropathy. In: High risk diabetic foot: treatment and prevention. Taylor & Francis, London, p 65

    Google Scholar 

  • Rother KI (2007) Diabetes treatment – bridging the divide. N Engl J Med 356(15):1499–1501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Russell JW, Zilliox LA (2014) Diabetic neuropathies. Continuum 20(5 Peripheral nervous system disorders):1226–1240

    PubMed  PubMed Central  Google Scholar 

  • Saadi H, Carruthers SG, Nagelkerke N, Al-Maskari F, Afandi B, Reed R, Lukic M, Nicholls MG, Kazam E, Algawi K, Al-Kaabi J, Leduc C, Sabri S, El-Sadig M, Elkhumaidi S, Agarwal M, Benedict S (2007) Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates. Diabetes Res Clin Pract 78:369–377

    Google Scholar 

  • Schalkwijk CG, Stehouwer CD (2005) Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin Sci 109(2):143–159

    Article  CAS  Google Scholar 

  • Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS (2002) Pathogenesis of atherosclerosis: a multifactorial process. Exp Clin Cardiol 7(1):40–53

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, Joh K (2010) Pathologic classification of diabetic nephropathy. J Am Soc Nephrol 21(4):556–563

    Article  PubMed  Google Scholar 

  • Tiganis T (2011) Reactive oxygen species and insulin resistance: the good, the bad and the ugly. Trends Pharmacol Sci 32(2):82–89

    Article  CAS  PubMed  Google Scholar 

  • Tyagi P (2000) Insulin delivery systems: present trends and the future direction. Indian J Pharmacol 34(6):379–389

    Google Scholar 

  • Uwaezuoke SN (2017) The role of novel biomarkers in predicting diabetic nephropathy: a review. Int J Nephrol Renov Dis 10(1):221–231

    Article  CAS  Google Scholar 

  • Vincent AM, Russell JW, Low P, Feldman EL (2004) Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev 25(4):612–628

    Article  CAS  PubMed  Google Scholar 

  • Vinik AI, Maser RE, Mitchell BD, Freeman R (2003) Diabetic autonomic neuropathy. Diabetes Care 26(5):1553–1579

    Article  PubMed  Google Scholar 

  • Volmer-Thole M, Lobmann R (2016) Neuropathy and diabetic foot syndrome. Int J Med Sci 17(6):917

    Google Scholar 

  • Wang DD, Bakhotmah BA, Hu FB, Alzahrani HA (2014) Prevalence and correlates of diabetic peripheral neuropathy in a Saudi Arabic population: a cross-sectional study. PLoS One 9

    Google Scholar 

  • Wang YT, Tadarati M, Wolfson Y, Bressler SB, Bressler NM (2016) Comparison of prevalence of diabetic macular edema based on monocular fundus photography vs optical coherence tomography. JAMA Ophthalmol 134(2):222–228

    Article  PubMed  Google Scholar 

  • Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97(18):1837–1847

    Article  CAS  PubMed  Google Scholar 

  • Wolf PA, D’Agostino RB, Belanger AJ, Kannel WB (1991) Probability of stroke: a risk profile from the Framingham study. Stroke 22(3):312–318

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization (1999a) Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. World Health Organization, Geneva

    Google Scholar 

  • World Health Organization (1999b) Population-based approaches to childhood obesity prevention. World Health Organization, Geneva

    Google Scholar 

  • World Health Organization (2016a) Diabetes country profiles. World Health Organization, Geneva

    Google Scholar 

  • World Health Organization (2016b) Proportional mortality (% of total deaths, all ages). World Health Organization, Geneva

    Google Scholar 

  • Wu YL, Ding Y, Tanaka Y, Zhang W (2014) Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci 11(11):1185–1200

    Article  PubMed  PubMed Central  Google Scholar 

  • Xie J, Méndez JD, Méndez-Valenzuela V, Aguilar-Hernández MM (2013) Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal 25(11):2185–2197

    Article  CAS  PubMed  Google Scholar 

  • Yao D, Brownlee M (2010) Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 59(1):249–255

    Article  CAS  PubMed  Google Scholar 

  • Yuan S, Larsson SC (2020) An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study. Diabetologia 63(1):2359–2371

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zakin E, Abrams R, Simpson DM (2019) Diabetic neuropathy. Semin Neurol 39(5):560–569

    Article  PubMed  Google Scholar 

  • Zayed H (2016) Epidemiology of diabetic ketoacidosis in Arab patients with type 1 diabetes: a systematic review. Int J Clin Pract 70(3):186–195

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Saaddine JB, Chou CF, Cotch MF, Cheng YJ, Geiss LS, Gregg EW, Albright AL, Klein BE, Klein R (2010) Prevalence of diabetic retinopathy in the United States, 2005–2008. JAMA 304(6):649–656

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zheng Y, Ley SH, Hu FB (2018) Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14(2):88–98

    Article  PubMed  Google Scholar 

  • Zimmermann MB, Boelaert K (2015) Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol 3(4):286–295

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Bio Engineering, Lancaster University, Lancaster, UK

    Rabia Khan

  2. Division of Dental Public Health, Department of Preventive Dental Sciences, College of Dentistry, University of Ha’il, Ha’il, Saudi Arabia

    Ammar Ahmed Siddiqui

  3. Division of Pediatric Dentistry, Department of Preventive Dental Sciences, College of Dentistry, University of Ha’il, Ha’il, Saudi Arabia

    Freah Alshammary

  4. Divisions of Oral Diagnosis and Oral Medicine, Department of OMFS and Diagnostic Sciences, College of Dentistry, University of Ha’il, Ha’il, Saudi Arabia

    Sameer Shaikh

  5. Department of Physiotherapy, College of Applied Medical Sciences, University of Ha’il, Ha’il, Saudi Arabia

    Junaid Amin

  6. College of Pharmacy, University of Ha’il, Ha’il, Saudi Arabia

    Hassaan Anwer Rathore

  7. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

    Hassaan Anwer Rathore

Authors
  1. Rabia Khan
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  2. Ammar Ahmed Siddiqui
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  3. Freah Alshammary
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  4. Sameer Shaikh
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  5. Junaid Amin
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  6. Hassaan Anwer Rathore
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Editor information

Editors and Affiliations

  1. Dept. Pharmacology Therapeutics, University of British Colombia Dept. Pharmacology Therapeutics, VANCOUVER, BC, Canada

    Ismail Laher

Section Editor information

  1. Niels Bohrs Vej 9-10, Unit for Health Promotion Research, University of Southern Denmark, Esbjerg, Jutland, Denmark

    Anastasia Samara

  2. Faculty of Health Science, Kristianstad University, Kristianstad, Sweden

    Atika Khalaf

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Khan, R., Siddiqui, A.A., Alshammary, F., Shaikh, S., Amin, J., Rathore, H.A. (2021). Diabetes in the Arab World. In: Laher, I. (eds) Handbook of Healthcare in the Arab World. Springer, Cham. https://doi.org/10.1007/978-3-319-74365-3_41-1

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  • DOI: https://doi.org/10.1007/978-3-319-74365-3_41-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-74365-3

  • Online ISBN: 978-3-319-74365-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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