Synonyms
Eccrine angiomatous hamartoma; EAH; Sudoriparous angiomatous hamartoma; Functioning sudoriparous angiomatous hamartoma; Nevus of the sweat gland; Cavernous angiomatosis of the sweat ducts
Definition and Characteristics
Hamartoma is a non-neoplastic proliferation of cells and tissue components that occurs in an affected area. In its EAH form, there is an increased number of eccrine secretory and ductal elements within the angiomatous channels.
Prevalence
Although adult onset has been reported, the disease is most commonly seen during early childhood. There is no apparent gender preference. EAH is a rare disorder with approximately 50 cases reported in the literature.
Genes
The genetic characteristics have not been demonstrated.
Molecular and Systemic Pathophysiology
EAH is a rare cutaneous hamartoma appearing histologically as a proliferation of eccrine sweat glands with angiomatous vascular elements that are of capillary origin. A deficiency between the mesenchyme and...
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References
Foshee JB, Grau RH, Adelson DM, Crowson N (2006) Pediatr Dermatol 23:365–368
Chien AJ, Asgari M, Argenyi ZB (2006) J Cutan Pathol 33:433–436
Sezer E, Koseoglu RD, Filiz N (2006) Br J Dermatol 154:1002–1004
Tay YH, Sim CS (2006) Pediatr Dermatol 23:516–517
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Sezer, E., Şenaylı, A. (2009). Angiomatous Hamartoma. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_111
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DOI: https://doi.org/10.1007/978-3-540-29676-8_111
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-67136-7
Online ISBN: 978-3-540-29676-8
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