Definition
Is the reversible, covalent attachment of SUMO, a ubiquitin-like protein (Ubl). Many proteins, such as transcription factors, are regulated by sumoylation. Often sumoylation acts antagonistic against ubiquitination, preventing proteins from being degraded. Sumoylation is important for the regulation of DNA damage repair and for the maintenance of genome integrity. There is evidence that sumoylation is involved in cancer metastasis.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). Sumoylation. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_5572
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DOI: https://doi.org/10.1007/978-3-642-16483-5_5572
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
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