Introduction
Although bone tissue possesses the capacity for regenerative growth, the bone repair process is impaired in many clinical and pathological situations. Large bone loss caused by trauma and tumor resection and/or aging, require reconstructive surgery and/or bone regeneration. At present, bone surgeons have three different possibilities when it comes to replacing bone.
Autogenous bone grafts are considered as the gold standard for bone replacement, in spite of large pain, septic complications, limited amount harvested from the iliac crest or other sites. Allogenic bone grafts obtained from tissue banks also have limitations because of the possible transmission of nonconventional agents or viruses and the risk of immunological incompatibility
Alloplastic Bone substitutes are produced in various compositions and shapes (Fig. 1). These biomaterials can be used alone to fill bone cavities, serving as a scaffold for bone regeneration from the peri-implant region. Bone substitutes...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- CaP:
-
Calcium Phosphate
- HA:
-
Hydroxyapatite
- CHA:
-
Carbonated Hydroxyapatite
- TCP:
-
Tricalcium Phosphate
- BCP:
-
Biphasic Calcium Phosphate
- MBCP:
-
Micro Macroporous Biphasic Calcium Phosphate
References
Albee FH. Studies in bone growth: triple calcium phosphate as a stimulus for osteogenesis. Ann Surg. 1920;71:32–6.
Basu B, Nath S. Fundamentals of biomaterials and biocompatibility. In: Basu B, Katti DS, Kumar A, editors. Advanced biomaterials: fundamentals, processing, and applications. New York: Wiley; 2009. p. 53–140.
Bohner M. Bioresorbable ceramics. In: Buchannan F, editor. Degradation rate of bioresorbale materials, prediction and evaluation. Cambridge: Woodhead Publishing Materials; 2008. p. 95–114.
Cho DY, Lee WY, Sheu PC, Chen CC. Cage containing a biphasic calcium phosphate ceramic (triosite) for the treatment of cervical spondylosis. Surg Neurol. 2005;63:497–503.
Daculsi G. Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute. Biomaterials. 1998;19:1473–8.
Daculsi G, Dard M. Bone-calcium-phosphate ceramic interface. Osteosynth Intern. 1994;2:153–6.
Daculsi G, LeGeros RZ. Tricalciumphosphate/hydroxyapatite biphasic calcium phosphate (BCP) bioceramics. In: Kokubo T, editor. Bioceramics and theirs clinical applications. Cambridge: Woodhead publishing; 2008. p. 395–424.
Daculsi G, LeGeros RZ, Heugheaert M, Barbieux I. Formation of carbonate apatite crystals after implantation of calcium phosphate ceramics. Calcif Tissue Int. 1990;46(20):27.
Daculsi G, Legeros RZ, Grimandi G, Soueidan A, Aguado E, Goyenvalle E, Legeros J. Effect of sintering process on microporosity and bone growth on biphasic calcium phosphate ceramics. Key Eng Mater. 2008;361–363:1139–42.
Daculsi G, Jegoux F, Layrolle P. The micro macroporous biphasic calcium phosphate concept for bone reconstruction and tissue engineering. In: Basu B, Katti DS, Kumar A, editors. Advanced biomaterials: fundamentals, processing, and applications. New York: Wiley; 2009. p. 101–41.
Daculsi G, Uzel AP, Weiss P, Goyenvalle E, Aguado E. Developments in injectable multiphasic biomaterials. The performance of microporous biphasic calcium phosphate granules and hydrogels. J Mater Sci Mater Med. 2010;3:855–61.
De Groot KD. Ceramics of calcium phosphate: preparation and properties. In: Groot KD, editor. Bioceramics of calcium phosphate. Boca Raton: CRC Press; 1983. p. 100–14.
De Santis R, Guarino V, Ambrosio L. Composite biomaterials for bone repair. In: Planell JA, editor. Bone repair biomaterials. Campbridge: Woodhead Publishing; 2009. p. 252–70.
Dorozhkin SV. Calcium orthophosphates as bioceramics: state of the art. J Funct Biomater. 2010;1:22–107.
Ducheyne P, Marcolongco M, Schepers E. Bioceramic composites. In: Hench LL, Wilson J, editors. An introduction to bioceramics. London: World Scientific; 1993. p. 281–97.
Gauthier O, Bouler JM, Aguado E, Legeros RZ, Pilet P, Daculsi G. Elaboration conditions influence physico chemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate bioceramics. J Mat Sci Mat In Med. 1999;10:199–204.
Ginebra MP. Cements as bone repair materials. In: Planell JA, editor. Bone repair biomaterials. Cambridge: Woodhead Publishing; 2009. p. 271–308.
Habibovic P, Gbureck U, Doillon CJ, Baset DC, Van Blitterswijk CA, Barralet JE. Osteoconduction and osteoinduction of low temperature 3D printed bioceramic implants. Biomaterials. 2008;29:944–53.
LeGeros RZ. Calcium phosphates in oral biology and medicine, Oral Sciences. Basel: S. Karger; 1991.
LeGeros RZ, Daculsi G. The in vivo behaviour of biphasic calcium phosphate. Histological, ultrastructural and physico chemical characterization. Amsterdam: CRC Press; 1990.
Legeros RZ, Daculsi G, Legeros J. Bioactive bioceramics, orthopaedic biology and medicine: musculoskeletal regeneration. In: Pietrazak WS, editor. Biological materials and methods. Totowa: Humana Press; 2009a. p. 153–81.
LeGeros RZ, Ito A, Ishikawa K, Sakae T, LeGeros J. Fundamentals of Hydroxyapatite and related calcium phosphate. In: Basu B, Katti DS, Kumar A, editors. Advanced biomaterials: fundamentals, processing, and applications. New York: Wiley; 2009b. p. 19–52.
Le Nihouannen D, Daculsi G, Saffarzadeh A, Gauthier O, Delplace S, Pilet P, Layrolle P. Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles. Bone. 2005;36:1086–93.
Nath S, Basu B. Materials for orthopaedic applications. In: Basu B, Katti DS, Kumar A, editors. Advanced biomaterials: fundamentals, processing, and applications. New York: Wiley; 2009. p. 53–140.
Acknowledgment
The authors thanks all the collaborators involved in the studies cited performed in Nantes University and INSERM EMI 99 03, Nantes Hospital, Nantes Microscopy SC3M department, and New York University College of Dentistry. This study was supported by FP7 framework EU program GAMBA NMP-2009-2.3-1
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 European Biophysical Societies' Association (EBSA)
About this entry
Cite this entry
Daculsi, G., Miramond, T. (2013). Calcium Phosphate–Derived Biomaterials. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_698
Download citation
DOI: https://doi.org/10.1007/978-3-642-16712-6_698
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16711-9
Online ISBN: 978-3-642-16712-6
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences