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Convection-Enhanced Delivery

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 82 Accesses

Synonyms

CED; High-flow microinfusion; Interstitial microinfusion; Intracerebral clysis; Intracerebral microinfusion

Definition

Convection-enhanced delivery (CED) is a novel delivery method that allows direct drug infusion into the brain in a locoregional manner. The delivery is accomplished through surgically implanted catheters in the brain that are connected to external drug infusion pumps that generate a positive infusion pressure. This positive pressure begins the process of convection, which is the augmentation and maintenance of the brain’s normal physiologic bulk flow of interstitial fluid. The enhanced bulk flow through the interstitial space acts as the carrier of the desired agent.

Characteristics

High-grade primary brain tumors, such as glioblastoma multiforme, remain one of the most challenging diagnoses to treat effectively. Despite a range of therapeutic options and their combinations, including surgical resection, external beam radiation therapy, and chemotherapy, the...

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References

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See Also

  • (2012) Cerebral Edema. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 750. doi: 10.1007/978-3-642-16483-5_1034

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  • (2012) Diffusion. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1116. doi: 10.1007/978-3-642-16483-5_1620

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  • (2012) Ependyma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1267. doi: 10.1007/978-3-642-16483-5_1926

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  • (2012) Gyrus. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1620. doi: 10.1007/978-3-642-16483-5_2542

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  • (2012) Interstitial Space. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1899. doi: 10.1007/978-3-642-16483-5_3110

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  • (2012) Liposomes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2063. doi: 10.1007/978-3-642-16483-5_3388

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  • (2012) Monoclonal Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2367. doi: 10.1007/978-3-642-16483-5_6842

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  • (2012) Pharmacokinetics. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2845. doi: 10.1007/978-3-642-16483-5_4500

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  • (2012) Subarachnoid Space. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3552. doi: 10.1007/978-3-642-16483-5_5546

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  • (2012) Sulcus. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3555. doi: 10.1007/978-3-642-16483-5_5559

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Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Kenji Muro

Authors
  1. Kenji Muro
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Corresponding author

Correspondence to Kenji Muro .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Muro, K. (2014). Convection-Enhanced Delivery. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1329-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1329-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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