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Cytokine Receptor as the Target for Immunotherapy and Immunotoxin Therapy

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  • First Online:
Encyclopedia of Cancer

  • 78 Accesses

Synonyms

Cancer vaccines; Cytokine receptor; Immunotherapy; Immunotoxins

Definition

Cancer immunotherapy is the treatment of cancer by improving the ability of a tumor-bearing individual to reject the tumor immunologically. In the case of immunotherapy targeting cytokine receptors, delivery of tumor antigen proteins induces immune response against cancer cells bearing such tumor antigen to eliminate them. Cytokine receptor-targeting immunotoxins are proteins containing a bacterial toxin or chemical compound along with an antibody or a ligand that binds specifically to its target receptor. Immunotoxins then internalize through the receptors and achieve cytotoxic effect derived from the toxin moiety.

Characteristics

When cancer cells are generated in a body, a variety of mechanisms cooperate in order to kill the cancer cells. Among these mechanisms, the immune system has an important role to eliminate tumor tissues. First, immunocytes like macrophagesand natural killer (NK) cells are...

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References

  • Kawakami K, Nakajima O, Morishita R et al (2006) Targeted anticancer immunotoxins and cytotoxic agents with direct killing moieties. Scientific World J 6:781–790

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  • Pastan I, Hassan R, Fitzgerald DJ et al (2006) Immunotoxin therapy of cancer. Nat Rev Cancer 6:559–565

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  • Schuster M, Nechansky A, Kircheis R (2006) Cancer immunotherapy. Biotechnol J 1:138–147

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See Also

  • (2012) CTL. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1012. doi: 10.1007/978-3-642-16483-5_1406

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  • (2012) Cytokine Receptor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1052. doi: 10.1007/978-3-642-16483-5_1475

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  • (2012) Diphtheria Toxin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1124. doi: 10.1007/978-3-642-16483-5_1636

    Google Scholar 

  • (2012) Pseudomonas Exotoxin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3112. doi: 10.1007/978-3-642-16483-5_4841

    Google Scholar 

  • (2012) Renal Cancer. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3225-3226. doi: 10.1007/978-3-642-16483-5_6575

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

    Koji Kawakami

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  1. Koji Kawakami
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Corresponding author

Correspondence to Koji Kawakami .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Kawakami, K. (2015). Cytokine Receptor as the Target for Immunotherapy and Immunotoxin Therapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1476-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1476-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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