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Drug Delivery Systems for Cancer Treatment

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 45 Accesses

Synonyms

DDS

Keywords

Tumor neovasculature; Drug delivery; Nanoparticles

Definition

Drug delivery systems (DDS) are defined as effective systems that deliver optimal amounts of drugs or chemicals to target tissues, enhancing drug efficacy and reducing adverse effects.

Characteristics

Drugs or chemicals for treatment of diseases are often tablets or solutions that are designed to enhance absorption in vivo. Efficient absorption, distribution, metabolism, and excretion during the process of drug delivery are major issues of drug therapies. However, diffusion of drugs before they reach to the target tissues occurs in many cases. Therefore, an amount of drugs properly targeting the desired tissues become low, and more importantly it is difficult to control the drug concentration in the disease foci. Furthermore, drugs must be administered in large amounts to exert their beneficial effects; therefore they affect normal cells, and adverse effects may occur.

Drug delivery systems are designed...

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References

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See Also

  • (2012) Liposomes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2063. doi:10.1007/978-3-642-16483-5_3388

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  • (2012) Nanoparticles. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2449. doi:10.1007/978-3-642-16483-5_3964

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  • (2012) Neovascularization. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2474. doi:10.1007/978-3-642-16483-5_4016

    Google Scholar 

  • (2012) Prodrug. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2989. doi:10.1007/978-3-642-16483-5_4751

    Google Scholar 

  • (2012) Sustained release. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3586. doi:10.1007/978-3-642-16483-5_5609

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science (ICMS), Fujita Health University, Toyoake, Japan

    Kunihiro Tsuchida

Authors
  1. Kunihiro Tsuchida
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Corresponding author

Correspondence to Kunihiro Tsuchida .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Tsuchida, K. (2015). Drug Delivery Systems for Cancer Treatment. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1734-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1734-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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