Definition
Are intercellular channel structures located in the plasma membranes of neighboring cells that mediate transfer of materials up to a molecular weight of 1,000 Da.
Characteristics
Transferred materials comprise ions, growth factors, and second messengers, among others. This transfer seems to be passive and nonselective. Channels (Ether à –go–go potassium channels) are formed by two hemichannels or connexons, every one embedded in the plasma membrane of adjacent cells and connected to each other to form hydrophilic, tube-like pores that allow transfer of material from one cell to another. In some cases, only one hemichannel is present allowing material to pass from the cell into the intercellular space. Individual channels accumulate in regions of the plasma membrane forming the typical plaques observed in the microscope. One plaque may contain up to 1,000 channels.
The connexons are formed by six molecules of connexinproteins, each of which contains four transmembrane...
References
Hertzberg EL, Lawrence TS, Gilula NB (1981) Gap junctional communication. Annu Rev Physiol 43:479–491
Loewenstein WR, Kanno Y (1966) Intercellular communication and the control of tissue growth: lack of communication between cancer cells. Nature 209:1248–1249
Mesnil M, Crespin S, Avanzo JL et al (2005) Defective gap junctional intercellular communication in the carcinogenic process. Biochim Biophys Acta 1719:125–145
Ott T, Jokwitz M, Lenhard D et al (2006) Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis. Eur J Cell Biol 85:717–7285
Solan JL, Lampe PD (2014) Specific Cx43 phosphorylation events regulate gap junctions turnover in vivo. FEBS Lett 588(8):1423–1429
Takeuchi H, Suzumura A (2014) Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases. Front Cell Neurosci. doi:10.3389/fncel.2014.00189
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Alonso, A. (2014). Gap Junctions. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_2325-2
Download citation
DOI: https://doi.org/10.1007/978-3-642-27841-9_2325-2
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences