Definition
Metastasis suppressors are a family of molecules functionally defined by their ability to block metastasis without blocking primary tumor growth. The suppressing activity could be the result of alterations at any of the steps in the multistep metastatic cascade.
Characteristics
To fully understand metastasis suppressors, it is first important to define a number of terms associated with carcinogenesis, tumor progression, invasion, and metastasis. Tumorigenesis refers to the acquired capacity of cells to proliferate in the absence of persistent stimulation by triggering carcinogenic agent(s). Tumor progression is the evolution of tumorigenic cells toward increasing malignancy. Invasion involves migration away from the primary tumor mass, involves breakdown of basement membranes, and usually involves secretion of proteinases. Metastasisis the process by which a malignant neoplastic cell(s) spreads to discontiguous sites and establishes secondary masses. In order to...
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References
Bohl CR, Harihar S, Denning WL, Sharma R, Welch DR (2014) Metastasis suppressors in breast cancer: mechanistic insights and clinical potential. J Mol Med (Berl) 92(1):13–30
Eccles SA, Welch DR (2007) Metastasis: recent discoveries and novel therapeutic strategies. Lancet 369:1742–1757. doi:10.1016/S0140-6736(07)60781-8
Liu W, Vivian CJ, Brinker AE, Hampton KR, Lianidou E, Welch DR (2014) Microenvironmental influences on metastasis suppressor expression and function during a metastatic cell’s journey. Cancer Microenviron. doi:10.1007/s12307-014-0148-4954-63/s12307-014-0148-4
See Also
(2012) Beta-catenin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 385. doi:10.1007/978-3-642-16483-5_889
(2012) BH3-interacting death domain agonist. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 389. doi:10.1007/978-3-642-16483-5_601
(2012) Drg-1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1160. doi:10.1007/978-3-642-16483-5_1730
(2012) Experimental metastasis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1361. doi:10.1007/978-3-642-16483-5_2062
(2012) Lung colony formation assay. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2115. doi:10.1007/978-3-642-16483-5_3436
(2012) Macrometastasis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2130. doi:10.1007/978-3-642-16483-5_3483
(2012) Malignant tumor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2150. doi:10.1007/978-3-642-16483-5_3519
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Welch, D.R., Sasaki, K., Al-Ani, G. (2015). Metastasis Suppressor Gene. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3673-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_3673-2
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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