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AAMP

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 58 Accesses

Definition

Angio-associated migratory cell protein; gene maps to chromosome 2q35. AAMP has been conserved in evolution, is distributed intracellularly in many cells and also extracellularly on vascular cells, shares an epitope with motility-related proteins (alpha-actinin and a fast twitch skeletal muscle protein), and contains potential heparin binding and thrombin cleavage sites. Antibody and antisense studies have indicated compartment (intracellular or extracellular) specific roles for AAMP in angiogenesis, cell-cell and cell-matrix interactions, and cell migration.

Characteristics

The cDNA derived from mRNA encoding AAMP was originally cloned from a human melanoma cell library (A2058) in a search for migration-related proteins. AAMP has been found in the cytoplasm of many nucleated cells, in an extracellular mesh-like network on monolayers of endothelial and vascular-associated smooth muscle cells, and on the apical membranes of endometrial glandular cells. AAMP expression when...

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References

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See Also

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  • (2012) Amino Terminal End. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 156. doi:10.1007/978-3-642-16483-5_224

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  • (2012) Epitope. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1297. doi:10.1007/978-3-642-16483-5_1966

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  • (2012) Phorbol Ester. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2865. doi:10.1007/978-3-642-16483-5_4522

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  • (2012) WD Repeats. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3945. doi:10.1007/978-3-642-16483-5_6233

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Marie E. Beckner

Authors
  1. Marie E. Beckner
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Correspondence to Marie E. Beckner .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Beckner, M.E. (2014). AAMP. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_6-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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