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XIAP

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 41 Accesses

Synonyms

API3; BIR-containing protein 4 (BIRC4); hIAP3; hIAP-3; IAP-3; ILP1; MIHA; X-linked inhibitor of apoptosis; XLP2

Definition

X-linked inhibitor of apoptosis, XIAP, is a protein that contains three baculovirus inhibitors of apoptosis protein repeat (BIR) domains as well as a UBA ubiquitin-binding domain and a really interesting new gene (RING) domain. XIAP functions to prevent apoptosis by binding to caspase-3, caspase-7, and caspase-9 to inhibit caspase activity.

Characteristics

Structure

The XIAP protein is 497 amino acids in length and migrates on denaturing polyacrylamide electrophoresis as a ~55 kDa band. XIAP contains BIR1, BIR2, and BIR3 domains which are the defining feature IAP proteins. Each BIR domain is a zinc-binding region of about 70 amino acids. XIAP also contains a ubiquitin-binding UBA domain. Finally, the C-terminus of XIAP contains a RING domain with E3 ubiquitin ligase activity. A schematic representation of XIAP is shown in Fig. 1.

Fig. 1
figure 1

XIAP protein...

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References

  • Bai L, Smith DC, Wang S (2014) Small-molecule SMAC mimetics as new cancer therapeutics. Pharmacol Ther 144(1):82–95

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  • Imre G, Larisch S, Rajalingam K (2011) Ripoptosome: a novel IAP-regulated cell death-signalling platform. J Mol Cell Biol 3(6):324–326

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See Also

  • (2012) Bcl-2 family proteins. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 361. doi:10.1007/978-3-642-16483-5_564

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  • (2012) BIR domain. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 416. doi:10.1007/978-3-642-16483-5_653

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  • (2012) Caspase-3. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 675. doi:10.1007/978-3-642-16483-5_874

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  • (2012) Caspase-9. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 678. doi:10.1007/978-3-642-16483-5_877

    Google Scholar 

  • (2012) SMAC/Diablo. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3440. doi:10.1007/978-3-642-16483-5_5359

    Google Scholar 

  • (2012) Ubiquitin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3825. doi:10.1007/978-3-642-16483-5_6083

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE, 68198-5870, USA

    Justin L. Mott

Authors
  1. Justin L. Mott
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Corresponding author

Correspondence to Justin L. Mott .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Mott, J.L. (2015). XIAP. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6283-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_6283-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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