Definition
Active specific immunmotherapy (immunotherapy) of cancer endeavors to direct the host’s own immune system against an antigen expressed by tumor cells to create an immune response that will destroy the established tumor. The same immune response induced in an adjuvant setting targets and intends to eliminate isolated disseminated tumor cells (micrometastasis) to prevent disease recurrence and to create a state of immune surveillance (immune surveillance of tumors) that will eliminate tumor cells as they arise. Passive immunotherapy uses monoclonal antibodies (MAbs; monoclonal antibody therapy) Monoclonal Antibodies for Cancer Therapy that bind to receptors or antigens on the tumor cell surface blocking receptor-ligand interactions and recruiting immune effector cells against the tumor. Trastuzumab (Herceptin®), a monoclonal antibody to human epidermal growth factor receptor 2 (HER2; HER2/neu; epidermal growth factor inhibitors), is already part of the standard treatment of...
This is a preview of subscription content, log in via an institution to check access.
References
Capdevila J, Elez E, Macarulla T, Ramos FJ, Ruiz-Echarri M, Tabernero J (2009) Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment. Cancer Treat Rev 35:354–363
Clinical trials. http://www.cancer.gov/clinicaltrials/; http://www.mrw.interscience.wiley.com/cochrane/cochrane_clcentral_articles_fs.html
Copier J, Dalgleish AG, Britten CM, Finke LH, Gaudernack G, Gnjatic S, Kallen K, Kiessling R, Schuessler-Lenz M, Singh H, Talmadge J, Zwierzina H, Håkansson L (2009) Improving the efficacy of cancer immunotherapy. Eur J Cancer 45:1424–1431
Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438:967–974
Finn OJ (2008) Cancer immunology. N Engl J Med 358:2704–2715
Hudis AC (2007) Trastuzumab – mechanism of action and use in clinical practice. N Engl J Med 357:39–51
Marshall JL, Gulley JL, Arlen PM et al (2005) Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J Clin Oncol 23(4):720–731
Rabinovich GA, Gabrilovich D, Sotomayor EM (2007) Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25:267–296
Tang C, Katsara M, Apostolopoulos V (2008) Strategies used for MUC1 immunotherapy: human clinical studies. Expert Rev Vaccines 7(7):963–975
Weiner LM, Dhodapkar MV, Ferrone S (2009) Monoclonal antibodies for cancer immunotherapy. Lancet 373:1033–1040
See also
(2012) Adjuvant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 75. doi:10.1007/978-3-642-16483-5_107
(2012) Antigen. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 209. doi:10.1007/978-3-642-16483-5_319
(2012) Antigen-presenting cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 209–210. doi:10.1007/978-3-642-16483-5_321
(2012) Autoimmunity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 312. doi:10.1007/978-3-642-16483-5_478
(2012) Avastin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 323. doi:10.1007/978-3-642-16483-5_6577
2012) Betacellulin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 385. doi:10.1007/978-3-642-16483-5_591
(2012) Capecitabine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 640. doi:10.1007/978-3-642-16483-5_828
(2012) Carboplatin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 641. doi:10.1007/978-3-642-16483-5_833
(2012) CD8. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 703. doi:10.1007/978-3-642-16483-5_917
(2012) DETOX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1101. doi:10.1007/978-3-642-16483-5_6652
(2012) EGFR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1211. doi:10.1007/978-3-642-16483-5_1828
(2012) Epiregulin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1291. doi:10.1007/978-3-642-16483-5_1954
(2012) Extracellular domain. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1362. doi:10.1007/978-3-642-16483-5_2066
(2012) Glycans. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1565. doi:10.1007/978-3-642-16483-5_2443
(2012) Helper CD4 T-cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1639. doi:10.1007/978-3-642-16483-5_2608
(2012) HER2. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1678. doi:10.1007/978-3-642-16483-5_2676
(2012) Idiotype. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1804. doi:10.1007/978-3-642-16483-5_2944
(2012) Immune response. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1815. doi:10.1007/978-3-642-16483-5_2977
(2012) Interferon gamma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1888. doi:10.1007/978-3-642-16483-5_3092
(2012) Interleukin-12. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1892. doi:10.1007/978-3-642-16483-5_3101
(2012) Lapatinib. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1980. doi:10.1007/978-3-642-16483-5_3277
(2012) Letrozole. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2005. doi:10.1007/978-3-642-16483-5_6650
(2012) MAGE. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2135. doi:10.1007/978-3-642-16483-5_6375
(2012) Monoclonal antibody therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2367–2368. doi:10.1007/978-3-642-16483-5_3823
(2012) MUC1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2384–2386. doi:10.1007/978-3-642-16483-5_3870
(2012) Neoadjuvant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2472. doi:10.1007/978-3-642-16483-5_4003
(2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331
(2012) Phagocytosis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2840. doi:10.1007/978-3-642-16483-5_4493
(2012) Prodrug. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2989. doi:10.1007/978-3-642-16483-5_4751
(2012) QS-21. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3127. doi:10.1007/978-3-642-16483-5_6653
(2012) Transforming growth factor alpha. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3758. doi:10.1007/978-3-642-16483-5_5915
(2012) Transgenic mice. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3763. doi:10.1007/978-3-642-16483-5_5921
(2012) Tumor-associated antigen. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3807–3808. doi:10.1007/978-3-642-16483-5_6017
(2012) Tyrosine kinase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3822. doi:10.1007/978-3-642-16483-5_6079
(2012) Vaccine therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3879. doi:10.1007/978-3-642-16483-5_6147
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
von Mensdorff-Pouilly, S. (2014). Breast Cancer Immunotherapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6630-2
Download citation
DOI: https://doi.org/10.1007/978-3-642-27841-9_6630-2
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences