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Bryostatin-1

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 31 Accesses

Definition

Bryostatins are a class of macrocyclic lactones. Bryostatins are potent modulators of Protein Kinase C (PKC). Bryostatin-1 was isolated from the marine invertebrate Bugula neritina. Bryostatin-1 is currently not available for commercial use.

Characteristics

Rationale for Targeting the PKC

PKC is a family of homologous serine/threonine protein Kinases that transduce signals linked to diverse cellular processes including proliferation, differentiation, angiogenesis, and apoptosis. The PKC family includes 12 isoforms subdivided into three major classes based on their cofactor requirements for activation. Aberrant regulation of the PKC enzymes activity has been demonstrated in a number of malignancies including: breast, colorectal, pancreatic, and non-small cell lung cancer.

Preclinical Activity of Bryostatin-1

Treatment of cancer cell lines with bryostatin-1 results in the activation of PKC. However, prolonged exposure to bryostatin-1 induces PKC inhibition most probably...

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References

  • Choi SH, Hyman T, Blumberg PM (2006) Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cdelta. Cancer Res 66:7261–7269

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  • Deacon EM, Pongracz J, Griffiths G et al (1997) Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis. Mol Pathol 50:124–131

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  • Kortmansky J, Schwartz GK (2003) Bryostatin-1: a novel PKC inhibitor in clinical development. Cancer Invest 21:924–936

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See Also

  • (2012) Kinase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1943. doi: 10.1007/978-3-642-16483-5_3217

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  • (2012) Thrombocytopenia. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3678. doi: 10.1007/978-3-642-16483-5_5792

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA

    Bassel El-Rayes

  2. Winship Cancer Institute of Emory University, Atlanta, GA, USA

    Bassel El-Rayes

Authors
  1. Bassel El-Rayes
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Corresponding author

Correspondence to Bassel El-Rayes .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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El-Rayes, B. (2015). Bryostatin-1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_745-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_745-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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