Definition
An “animal model” of pain refers to a nonhuman animal treated in a manner to create a condition that mimics a painful human syndrome or disease. The model can then be used both to improve knowledge of mechanisms that might underlie the condition/disease and its relation to pain and to develop better treatments.
Introduction
Models of visceral pain usually refer to nonhuman animals that currently have or have had some type of pathophysiology of an internal organ. For female reproductive organs, the models are created in ways that mimic pain associated with female reproductive organs, i.e., gynecological pain. Importantly, however, as discussed below, such pain can sometimes be derived from...
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References
Berkley, K. J., & McAllister, S. L. (2011). Don't dismiss dysmenorrhea! Pain, 152, 1940–1941.
Berkley, K. J., Wood, E., Scofield, S. L., & Little, M. (1995). Behavioral responses to uterine or vaginal distension in the rat. Pain, 61, 121–131.
Berkley, K. J., McAllister, S. L., Accius, B. E., & Winnard, K. P. (2007). Endometriosis-induced vaginal hyperalgesia in the rat: Effect of estropause, ovariectomy, and estradiol replacement. Pain, 132(Suppl 1), S150–S159.
Bradshaw, H. B., & Berkley, K. J. (2002). Estrogen replacement reverses ovariectomy-induced vaginal hyperalgesia in the rat. Maturitas, 41, 157–165.
Bradshaw, H. B., & Berkley, K. J. (2003). The influence of ovariectomy with or without estrogen replacement on responses of rat gracile nucleus neurons to stimulation of hindquarter skin and pelvic viscera. Brain Research, 986, 82–90.
Bradshaw, H. B., Temple, J. L., Wood, E., & Berkley, K. J. (1999). Estrous variations in behavioral responses to vaginal and uterine distention in the rat. Pain, 82, 187–197.
Cason, A. M., Samuelsen, C. L., & Berkley, K. J. (2003). Estrous changes in vaginal nociception in a rat model of endometriosis. Hormones and Behavior, 44, 123–131.
Dmitrieva, N., Nagabukuro, H., Resuehr, D., Zhang, G., McAllister, S. L., McGinty, K. A., Mackie, K., & Berkley, K. J. (2010). Endocannabinoid involvement in endometriosis. Pain, 151, 703–710.
Dmitrieva, N., Faircloth, E. K., Pyatok, S., Sacher, F., & Patchev, V. (2012). Telemetric assessment of referred vaginal hyperalgesia and the effect of indomethacin in a rat model of endometriosis. Frontiers in Pharmacology, 3, 158.
Farmer, M. A., Taylor, A. M., Bailey, A. L., Tuttle, A. H., MacIntyre, L. C., Milagrosa, Z. E., Crissman, H. P., Bennett, G. J., Ribeiro-da-Silva, A., Binik, Y. M., & Mogil, J. S. (2011). Repeated vulvovaginal fungal infections cause persistent pain in a mouse model of vulvodynia. Science Translational Medicine, 3, 101ra91.
Giamberardino, M. A., & Vecchiet, L. (1995). Visceral pain, referred hyperalgesia and outcome: New concepts. European Journal of Anaesthesiology, Supplement, 10, 61–66.
Giamberardino, M. A., Valente, R., de Bigontina, P., & Vecchiet, L. (1995). Artificial ureteral calculosis in rats: Behavioural characterization of visceral pain episodes and their relationship with referred lumbar muscle hyperalgesia. Pain, 61, 459–469.
Giamberardino, M. A., Berkley, K. J., Affaitati, G., Lerza, R., Centurione, L., Lapenna, D., & Vecchiet, L. (2002). Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats. Pain, 95, 247–257.
Gintzler, A. R., & Komisaruk, B. R. (1991). Analgesia is produced by uterocervical mechanostimulation in rats: Roles of afferent nerves and implications for analgesia of pregnancy and parturition. Brain Research, 566, 299–302.
Gintzler, A. R., Peters, L. C., & Komisaruk, B. R. (1983). Attenuation of pregnancy-induced analgesia by hypogastric neurectomy in rats. Brain Research, 277, 186–188.
Li, B., Tong, C., & Eisenach, J. C. (2008). Pregnancy increases excitability of mechanosensitive afferents innervating the uterine cervix. Anesthesiology, 108, 1087–1092.
Li, Y., Zhang, S. F., Zou, S. E., Xia, X., & Bao, L. (2011). Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis. Reproductive Biology and Endocrinology, 9, 30.
McAllister, S. L., Dmitrieva, N., & Berkley, K. J. (2012). Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One, 7, e31758.
Morrison, T. C., Dmitrieva, N., Winnard, K. P., & Berkley, K. J. (2006). Opposing viscerovisceral effects of surgically induced endometriosis and a control abdominal surgery on the rat bladder. Fertility and Sterility, 86(4 Suppl), 1067–1073.
Nagabukuro, H., & Berkley, K. J. (2007). Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat. Pain, 132(Suppl 1), S96–103.
Ness, T. J., & Gebhart, G. F. (1988). Colorectal distension as a noxious visceral stimulus: Physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Research, 450, 153–169.
Ness, T. J., Lewis-Sides, A., & Castroman, P. (2001). Characterization of pressor and visceromotor reflex responses to bladder distention in rats: Sources of variability and effect of analgesics. Journal of Urology, 165, 968–974.
Sandner-Kiesling, A., Pan, H. L., Chen, S. R., James, R. L., DeHaven-Hudkins, D. L., Dewan, D. M., & Eisenach, J. C. (2002). Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain, 96, 13–22.
Shin, S. W., & Eisenach, J. C. (2003). Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner. Anesthesiology, 98, 1467–1471.
Shin, S. W., Sandner-Kiesling, A., & Eisenach, J. C. (2003). Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats. Pain, 105, 109–114.
Stratton, P., & Berkley, K. J. (2011). Chronic pelvic pain and endometriosis: Translational evidence of the relationship and implications. Human Reproduction Update, 17, 327–346.
Temple, J., Bradshaw, H. B., Wood, E., & Berkley, K. J. (1999). Effects of hypogastric neurectomy on escape responses to uterine distention in the rat. Pain, 6, S13–20.
Tong, C., Ma, W., Shin, S. W., James, R. L., & Eisenach, J. C. (2003). Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord. Anesthesiology, 99, 205–211.
Tong, C., Conklin, D., Clyne, B. B., Stanislaus, J. D., & Eisenach, J. C. (2006). Uterine cervical afferents in thoracolumbar dorsal root ganglia express transient receptor potential vanilloid type 1 channel and calcitonin gene-related peptide, but not P2X3 receptor and somatostatin. Anesthesiology, 104, 651–657.
Vernon, M. W., & Wilson, E. A. (1985). Studies on the surgical induction of endometriosis in the rat. Fertility and Sterility, 44, 684–694.
Wesselmann, U., & Lai, J. (1997). Mechanisms of referred visceral pain: Uterine inflammation in the adult virgin rat results in neurogenic plasma extravasation in the skin. Pain, 73, 309–317.
Wesselmann, U., Czakanski, P. P., Affaitati, G., & Giamberardino, M. A. (1998). Uterine inflammation as a noxious visceral stimulus: Behavioral characterization in the rat. Neuroscience Letters, 246, 73–76.
Winnard, K. P., Dmitrieva, N., & Berkley, K. J. (2006). Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: Modulation by estrous stage and involvement of the hypogastric nerve. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 291, R1592–R1601.
Yan, T., Liu, B., Du, D., Eisenach, J. C., & Tong, C. (2007). Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function. Anesthesia and Analgesia, 104, 1246–1250.
Acknowledgments
Studies cited from the authors’ laboratory were supported by NIH grant RO1 NS 11892, with the exception of Dmitrieva et al. 2012, which was supported by Bayer HealthCare Pharmaceuticals.
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Berkley, K.J., Dmitrieva, N. (2013). Visceral Pain Models, Female Reproductive Organ Pain. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_4799
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DOI: https://doi.org/10.1007/978-3-642-28753-4_4799
Publisher Name: Springer, Berlin, Heidelberg
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