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Metastatische Tumoren des zentralen Nervensystems

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Klinische Neurologie

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Zusammenfassung

Sekundäre Hirntumoren sind Metastasen eines extrazerebralen Primärtumors, dessen Tochterzellen in der Regel hämatogen ins Gehirn gelangen. Hirnmetastasen treten bei 20–40 % aller Krebserkrankungen auf. Die häufigsten Primärtumoren sind Bronchialkarzinom, Mammakarzinom, Melanom, gastrointestinale Tumoren und Nierenzellkarzinom.

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Literatur

Zitierte Literatur

  • Andrews DW, Scott CB, Sperduto PW et al (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672

    Article  Google Scholar 

  • Aoyama H, Shirato H, Tago M et al (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgrey alone for treatment of brain metastases: a randomised controlled trial. J Am Med Assoc 295:2483–2491

    Article  CAS  Google Scholar 

  • Bachelot T, Romieu G, Campone M et al (2013) Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study. Lancet Oncol 14:64–71

    Article  CAS  Google Scholar 

  • Brown PD, Pugh S, Laack NN, for the Radiation Therapy Oncology Group (RTOG) et al (2013) Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro-Oncology 15:1429–1437

    Article  CAS  Google Scholar 

  • Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, NNI L, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D (2017) Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol 18(8):1049–1060. https://doi.org/10.1016/S1470-2045(17)30441-2. Epub 2017 Jul 4

    Article  PubMed  PubMed Central  Google Scholar 

  • Davies MA, Robert C, Long GV, Grob JJ, Flaherty KT, Arance A, Chiarion-Sileni V, Thomas L, Lesimple T, Mortier L, Moschos SJ, Hogg D, Rodas IM, Vecchio MD, Lebbe C, Meyer N, Zhang Y, Huang Y, Mookerjee B, Saiag P (2017) COMBI-MB: a phase II study of combination dabrafenib (D) and trametinib (T) in patients (pts) with BRAF V600–mutant (mut) melanoma brain metastases (MBM). J Clin Oncol 35(15_suppl):9506–9506. https://doi.org/10.1200/JCO.2017.35.15_suppl.9506

    Article  Google Scholar 

  • Di Giacomo AM, Ascierto PA, Queirolo P et al (2015) Three-year follow-up of advanced melanoma patients who received ipilimumab plus fotemustine in the Italian Network for Tumor Biotherapy (NIBIT)-M1 phase II study. Ann Oncol 26(4):798–803. https://doi.org/10.1093/annonc/mdu577. Epub 2014 Dec 23

    Article  PubMed  Google Scholar 

  • Fischer F, Haenel M, Moehle R et al (2011) Systemic and intrathecal chemotherapy followed by high-dose chemotherapy with autologous stem cell transplantation (HD-ASCT) for CNS relapse of aggressive lymphomas: a potentially curative approach? J Clin Oncol 29(Suppl):8005

    Article  Google Scholar 

  • Fischer L, Martus P, Weller M et al (2008) Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients. Neurology 71:1102–1108

    Article  CAS  Google Scholar 

  • Fuentes R, Bonfill X, Exposito J (2006) Surgery versus radiosurgery for patients with a solitary brain metastasis from non-small cell lung cancer. Cochrane Database Syst Rev 1:CD004840

    Google Scholar 

  • Garell PC, Hitchon PW, Wen BC et al (1999) Stereotactic radiosurgery versus microsurgical resection for the initial treatment of metastatic cancer to the brain. J Radiosurg 2:1–5

    Article  Google Scholar 

  • Gaspar L, Scott C, Rotman M et al (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37:745–751

    Article  CAS  Google Scholar 

  • Hussain A, Brown PD, Stafford SL et al (2007) Stereotactic radiosurgery for brainstem metastases: survival, tumor control, and patient outcomes. Int J Radiat Oncol Biol Phys 67:521–524

    Article  Google Scholar 

  • Kocher M, Soffietti R, Abacioglu U, for the EORTC Radiation Oncology and Brain Tumor Groups et al (2011) Adjuvant whole brain radiotherapy versus observation after radiosurgery or surgical resection of 1–3 cerebral metastases. results of the EORTC 22952-26001 study. J Clin Oncol 29:134–141

    Google Scholar 

  • Korfel A, Elter T, Thiel E et al (2013) Phase II study of CNS-directed chemotherapy uncluding high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas. Haematologica 98:364–370

    Article  CAS  Google Scholar 

  • Linskey ME, Andrews DW, Asher AL et al (2010) The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neuro-Oncol 96:45–68

    Article  Google Scholar 

  • Long GV, Atkinson V, Menzies AM, Lo S, Guminski AD, Brown MP, Gonzalez MM, Diamante K, Sandhu SK, Scolyer RA, Emmett L, McArthur GA (2017) A randomized phase II study of nivolumab or nivolumab combined with ipilimumab in patients (pts) with melanoma brain metastases (mets): the Anti-PD1 Brain Collaboration (ABC). J Clin Oncol 35(15_suppl):9508–9508. https://doi.org/10.1200/JCO.2017.35.15_suppl.9508

    Article  Google Scholar 

  • Mahajan A, Ahmed S, MF MA, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, IE MC, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G (2017) Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. Lancet Oncol 18(8):1040–1048. https://doi.org/10.1016/S1470-2045(17)30414-X. Epub 2017 Jul 4

    Article  PubMed  PubMed Central  Google Scholar 

  • Mavrakis AN, Halpern EF, Barker FG 2nd et al (2005) Diagnostic evaluation of patients with a brain mass as the presenting manifestation of cancer. Neurology 65:908–911

    Article  CAS  Google Scholar 

  • Patchell RA, Tibbs PA, Walsh JW et al (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500

    Article  CAS  Google Scholar 

  • Patchell RA, Tibbs PA, Regine WF et al (1998) Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 280:1485–1489

    Article  CAS  Google Scholar 

  • Patil CG, Pricola K, Garg SK et al (2012) Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases. Cochrane Database Syst Rev (9):CD006121

    Google Scholar 

  • Schackert G, Lindner C, Petschke S et al (2013) Retrospective study of 127 surgically treated patients with multiple brain metastases: indication, prognostic factors, and outcome. Acta Neurochir 155:379–387

    Article  Google Scholar 

  • Schoggl A, Kitz K, Reddy M et al (2000) Defining the role of stereotactic radiosurgery versus microsurgery in the treatment of single brain metastases. Acta Neurochir 142:621–626

    Article  CAS  Google Scholar 

  • Sloot S et al (2018) Improved survival of patients with melanoma brain metastases in the era of targeted BRAF and immune checkpoint therapies. Cancer 124:297–305

    Article  CAS  Google Scholar 

  • Sperduto PW, Berkey B, Gaspar LE et al (2008) A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database. Int J Radiat Oncol Biol Phys 70:510–514

    Article  Google Scholar 

  • Sperduto PW, Chao ST, Sneed PK et al (2010) Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multiinstitutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys 77:655–661

    Article  Google Scholar 

  • Sperduto PW, Kased N, Roberge D et al. (2012) Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol. 30(4):419–25. https://doi.org/10.1200/JCO.2011.38.0527. Epub 2011 Dec 27.

    Article  PubMed  Google Scholar 

  • Suh JH (2010) Stereotactic radiosurgery for the management of brain metastases. N Engl J Med 362:1119–1127

    Article  CAS  Google Scholar 

  • Valiente M, Ahluwalia MS, Boire A, Brastianos PK, Goldberg SB, Lee EQ, Le Rhun E, Preusser M, Winkler F, Soffietti R (2018) The evolving landscape of brain metastasis. Trends Cancer 4(3):176–196. https://doi.org/10.1016/j.trecan.2018.01.003. Epub 2018 Feb 21. Review

    Article  PubMed  PubMed Central  Google Scholar 

  • Vecht CJ, Haaxma-Reiche H, Noordijk EM et al (1993) Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33:583–590

    Article  CAS  Google Scholar 

  • Weller M (Hrsg) (2008a) Für die Neuro-Onkologische Arbeitsgemeinschaft (NOA) in der Deutschen Krebsgesellschaft. Leitlinie Diagnostik und Therapie der zerebralen Metastasen. Zuckschwerdt, München

    Google Scholar 

  • Weller M (Hrsg) (2008b) Für die Neuro-Onkologische Arbeitsgemeinschaft (NOA) in der Deutschen Krebsgesellschaft. Leitlinie Diagnostik und Therapie der Spinalen Metastasen und der Meningeosis neoplastica. Zuckschwerdt, München

    Google Scholar 

  • Yamamoto M, Serizawa T, Shuto T et al (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15(4):387–395. https://doi.org/10.1016/S1470-2045(14)70061-0. Epub 2014 Mar 10

    Article  PubMed  Google Scholar 

  • Yen CP, Sheehan J, Patterson G et al (2006) Gamma knife surgery for metastatic brain stem tumors. J Neurosurg 105:213–219

    Article  Google Scholar 

Weiterführende Literatur

  • Diener HC, Putzki N, für die DGN et al (Hrsg) (2008) Leitlinien für Diagnostik und Therapie in der Neurologie. Thieme, Stuttgart

    Google Scholar 

  • Louis DN, Ohgaki H, Wiestler OD et al (2007) World Health Organization classification of tumours. Pathology and genetics of tumours of the nervous system. The International Agency for Research on Cancer (IARC), 4th Aufl. IARC Press, Lyon

    Google Scholar 

  • Schlegel U, Weller M, Westphal M (Hrsg) (2009) Neuroonkologische Therapie. Kohlhammer, Stuttgart

    Google Scholar 

  • Tonn J-C, Westphal M, Rutka JT et al (Hrsg) (2010) Oncology of CNS tumors. Springer, Berlin/Heidelberg/New York/Tokyo

    Google Scholar 

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Correspondence to Martin Glas .

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Glas, M., Scheffler, B., Kebir, S. (2020). Metastatische Tumoren des zentralen Nervensystems. In: Berlit, P. (eds) Klinische Neurologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44768-0_96-1

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