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Raman Spectroscopy as a Biomarker-Investigative Tool in Bone Metabolism

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Biomarkers in Bone Disease

Abstract

Bone is a living material with a composite structure that endures long and repetitive shocks caused by walking or jumping. Currently, clinical imaging modalities do not completely characterize the quality of bone. Additionally, these approaches are inadequate for detecting the earliest disease stages, for determining the age, or for verifying the treatment impact. Raman spectroscopy is an easy technique that provides a fingerprint of the chemical and structural composition of bone. Thus, it allows the determination of biomarkers for the quantification of bone quality and to qualify the evolution with physiological changes and diseases as in osteoporosis and osteogenesis imperfecta.

Catherine Bosser and Agathe Ogier contributed equally to this work.

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Abbreviations

BMD:

Bone mineral density

BP:

Bisphosphonate

FWMH:

Full width at maximum height

GAG:

Glycosaminoglycan

IR:

Infrared spectroscopy

MicroCT:

Micro-computed tomography

NIR:

Near infrared

PCA:

Principal component analysis

PG:

Proteoglycan

RS:

Raman spectroscopy

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    Authors and Affiliations

    1. Ingénierie et Vieillissement des Tissus Vivants, Centrale Innovation, Centre Scientifique Auguste Moiroux, 69130, Ecully Cedex, France

      Catherine Bosser & Thierry Hoc

    2. UMR CNRS 5513, Laboratoire de Tribologie et Dynamique des Systèmes, Ecole Centrale de Lyon, 36, avenue Guy de Collongues, 69134, Ecully Cedex, France

      Agathe Ogier & Laurianne Imbert

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    1. Catherine Bosser
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    2. Agathe Ogier
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    3. Laurianne Imbert
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    4. Thierry Hoc
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    Correspondence to Catherine Bosser or Agathe Ogier .

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    Editors and Affiliations

    1. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom

      Vinood B. Patel

    2. Department of Nutrition and Dietetics, Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

      Victor R. Preedy

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    Bosser, C., Ogier, A., Imbert, L., Hoc, T. (2017). Raman Spectroscopy as a Biomarker-Investigative Tool in Bone Metabolism. In: Patel, V., Preedy, V. (eds) Biomarkers in Bone Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7693-7_31

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