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XtalFluor Deoxofluorination

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

The introduction of fluorine atoms into organic molecules often alters the latter’s chemical, physical, and biological properties [1]; and many developed pharmaceuticals and agrochemicals contain at least one fluorine atom. The unique effect of fluorine substitution has intrigued widespread interest and increasing demand for the synthesis of organofluorine compounds. Among various methodologies for incorporating fluorine atoms [2,3,4,5,6], deoxofluorination plays a significant role and numerous deoxofluorination reagents have been developed [6,7,8,9,10].

Nowadays, diethylaminosulfur trifluoride (DAST) and bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor) are the most widely used sulfur-based deoxofluorination reagents [11]. Compared to their parent gaseous reagent SF4 [12], DAST and Deoxo-Fluor are liquid, which means that they are easier to operate and more convenient to store. These two deoxofluorination reagents show high reactivity towards alcohols, aldehydes,...

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References

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Author information

Authors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

    Junkai Guo & Jinbo Hu

Authors
  1. Junkai Guo
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  2. Jinbo Hu
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Corresponding author

Correspondence to Jinbo Hu .

Editor information

Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. R&D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd, Taizhou, Zhejiang, China

    Teruo Umemoto

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Guo, J., Hu, J. (2019). XtalFluor Deoxofluorination. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-1855-8_65-1

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  • DOI: https://doi.org/10.1007/978-981-10-1855-8_65-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1855-8

  • Online ISBN: 978-981-10-1855-8

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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