Abstract
It was shown that the reaction of α-(het)aryl-2,4-dihydroxy- and 2,4,6-trihydroxyacetophenones with acetoformic anhydride catalyzed by sodium formate is an effective method for the preparation of chromones containing a heteroaromatic residue at the 3-position. The yield of the chromone and the rate of the reaction increase with increase in the π-deficiency of this residue or in the presence of a hydroxy group in the 6-position of the starting acetophenone. In the last case the method is also applicable to the preparation of the difficulty available 3-aryl-5,7-dihydroxychromones. Chromones with a nitrogencontaining residue are formed without the use of any catalyst.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 625–631, May, 1991.
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Pivovarenko, V.G., Khilya, V.P. Acetoformic anhydride in the synthesis of chromones. 1. Synthesis of 3-hetarylchromones. Chem Heterocycl Compd 27, 496–501 (1991). https://doi.org/10.1007/BF00473991
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DOI: https://doi.org/10.1007/BF00473991