Abstract
A method for the preparation of 2,4,8-trioxo-6-methyl derivatives of pyrimido[5,4-d]pyrimidine with various alkyl residues in the 7 position is described. It is shown that the chlorine in the 4 position of the 2,4-dichloro derivative of pyrimido[5,4-d]pyrimidine is the most labile in nucleophilic substitution reactions.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 517–520, April, 1977.
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Britikova, N.E., Elina, A.S. Synthesis and properties of some pyrimido[5,4-d]pyrimidine derivatives. Chem Heterocycl Compd 13, 417–420 (1977). https://doi.org/10.1007/BF00482788
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DOI: https://doi.org/10.1007/BF00482788