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Synthesis of aminoindoles by the Bucherer reaction

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of 5-hydroxyindoles with ammonia, alkylamines, or dialkylamines in the presence of sulfites leads to the corresponding 5-aminoindoles. Partial or complete elimination of the substituent is observed in the case of indoles that have an electron-acceptor substituent (COOC2H5, COCH3).

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, 117234, Moscow

    A. N. Kost, V. I. Terenin & L. G. Yudin

Authors
  1. A. N. Kost
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  2. V. I. Terenin
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  3. L. G. Yudin
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 786–789, June, 1979.

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Kost, A.N., Terenin, V.I. & Yudin, L.G. Synthesis of aminoindoles by the Bucherer reaction. Chem Heterocycl Compd 15, 639–642 (1979). https://doi.org/10.1007/BF00539499

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  • DOI: https://doi.org/10.1007/BF00539499

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