Summary
A short synthesis of 4-methylene glutamic acid was achieved. Under thermal conditions the corresponding anhydride reacted with 2,3 dimethylbutadiene to afford the corresponding DIELS-ALDER adduct in good yield. L-4-methylene glutamic acid essentially acts on glutamate metabotropic receptors and is as potent as L-Glu in producing IPs.
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Receveur, J.M., Roumestant, M.L. & Viallefont, P. Neuroexcitatory amino acids: 4-methylene glutamic acid derivatives. Amino Acids 9, 391–395 (1995). https://doi.org/10.1007/BF00807276
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DOI: https://doi.org/10.1007/BF00807276