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Effects of CuDIPS and tween 80 on SJL/J tumorigenesis

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Abstract

Plasma copper and zinc levels were measured in SJL/J mice, an inbred strain characterized by a high, spontaneous incidence of reticulum cell sarcoma (RCS). The changes with age in mean concentrations of these metals were consistent with a physiological response that is required for remission of neoplasia. Treatment of SJL/J mice with a copper complex, Cu(II)(3,4-diisopropylsalicylate)2 (Cu 3,5-DIPS), dissolved in a 10% Tween 80-saline solution revealed a decrease in survival and decline in the incidence of RCS at 52 wk of age. The toxic effects of Cu 3,5-DIPS therapy appeared to be related to the intraperitoneal route of administration and to extracellular deposition of collagen. The inhibitory effect on tumor development was not related to Cu 3,5-DIPS. Rather, Tween 80 was found to be the factor of importance.

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Authors and Affiliations

  1. Department of Biology, University of Alabama at Birmingham, University Station, 35294, Birmingham, Alabama

    Charles G. Crispens

  2. Department of Medicinal Chemistry, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W. Markham, 72205, Little Rock, Arkansas

    Philip S. Porter & John R. J. Sorenson

Authors
  1. Charles G. Crispens
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  2. Philip S. Porter
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  3. John R. J. Sorenson
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Crispens, C.G., Porter, P.S. & Sorenson, J.R.J. Effects of CuDIPS and tween 80 on SJL/J tumorigenesis. Biol Trace Elem Res 10, 19–24 (1986). https://doi.org/10.1007/BF02795315

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  • DOI: https://doi.org/10.1007/BF02795315

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