Abstract
Ni(II)-dien complex was prepared and characterized by X-ray diffraction. The crystal belongs to triclinic system, space group P-1, with crystallographic parametersa=0.888 13(18) nm,b=0.890 10(18) nm,c=1. 591 8(3) nm, α=77.71(3)°, β=89.12(3)°, γ=61.24(3)°,Z=2. The two dien molecules coordinate to the central Ni atom, the six nitrogen atoms form a distorted octahedron. Preliminary pharmacological tests showed this complex had antitumor activity against HepG2 and HL-60 cell linesin vitro.
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References
Thomas T, Thomas T J. Polyamines in Cell Growth and Cell Death: Molecular Mechanisms and Therapeutic Applications.Cell Mol Life Sci, 2001,58:244–258.
Shah N, Antony T, Haddad S, eitet al. Antitumor Effects of Bis(ethyl)Polyamines Analogs on Mammary Tumor Development in FVB/NTgN (MMTVneu) Transgenic Mice.Cancer Lett, 1999,146:15–23.
Fraser A V, Woster P M, Wallace H M. Induction of Apoptosis in Human Leukaemic Cells by IPENSpm, a Novel Polyamine Analogue and Anti-Metabolite.Biochem J, 2002,367:307–312.
Kingsnorth A N, Wallace H M, Bundred N J,et al. Polyamines in Breast Cancer.Br J Surgery, 1984,71:352–356.
Kingsnorth A N, Lumsden A B, Wallace H M. Polyamines in Colorectal Cancer.Br J Surgery, 1984,71:791–794
Yoshinari K, Yamazaki K, Komiyama M. Oligoamines as Simple and Efficient Catalysts for RNA Hydrolysis.J Am Chem Soc, 1991,113:5899–5901.
Komiyama M, Yoshinari K. Kinetic Analysis of Diamine-Catalyzed RNA Hydrolysis.J Org Chem, 1997,62:2155–2160.
Carotti S, Guerri A, Mazzei T,et al. Gold (III) Compounds as Potential Antitumor Agents: Cytotoxicity and DNA Binding Properties of Some Selected Polyamine-Gold (III) Complexes.Inorg Chim Acta, 1998,281:90–94.
Messori L, Abbate F, Marcon G,et al. Gold(III) Complexes as Potential Antitumor Agents: Solution Chemistry and Cytotoxic Properties of Some Selected Gold(III) Compounds.J Med Chem, 2000,43:3541–3548.
Wu M H, Cheng G P, He Y B,et al. A Practical Synthesis of Hydroxyl-N-Tosylcyclams via Cyclization of 1,3-Dichloro-2-Propanol with Disodium Di (poly)-N-Tosylamides.Syn Commun, 1995,25:1427–1431.
Xue G P, Liu Y, Wu C T. A Practical Synthesis of Novel Hydroxyl-Substituted Macrocyclic Tri-, Tetra- and Hexa-Amines.Chin J Chem, 1998,16:538–541.
Liang F, Wu X, Zhang S,et al. A Convenient Synthesis and Crystal Structure of Octahydro-Pyrazino[1, 2-a] Pyrazine.Syn Commun, 2004,34:827–833.
Liang F, Wu C T, Li Z Y,et al. Synthesis and Antitumor Activities of Hydroxyl-Substituted Macrocyclic Polyamines and Their Complexes.Chemical Journal on Internet, 2003,5:6.
Liang F, Wu C T, Lin H,et al. Copper Complex of Hydroxyl-Substituted Triazamacrocyclic Ligand and Its Antitumor Activity.Bioorg Med Chem Lett, 2003,13:2469–2472.
Liang Feng, Wei Jun, Li Zhao-yang,et al. Hydroxyl Macrocyclic Polyamines Coordination Systems Interaction with DNA and Their Antitumor Activitiesin vitro.Chem J Chin Univ, 2004,25:1190–1193 (Ch).
Liang F, Wang P, Zhou X,et al. Nickle(II) and Cobalt(II) Complexes of Hydroxyl-Substituted Triazamacrocyclic Ligand as Potential Antitumor Agents.Bioorg Med Chem Lett, 2004,14(7):841–844.
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Foundation item, Supported by the National Natural Science Foundation of China (29972034)
Biography: Li Tao (1976-), male, Ph. D candidate, research direction: ophthalmology and chemicalbiology.
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Tao, L., Feng, L., Shi-wei, Z. et al. Synthesis, structure and antitumor activities of [Ni(dien)2][Ni(CN)4] complex. Wuhan Univ. J. Nat. Sci. 9, 229–233 (2004). https://doi.org/10.1007/BF02830608
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DOI: https://doi.org/10.1007/BF02830608