Skip to main content
Log in

Serum iron, copper and zinc status in maternal and cord blood

  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Pregnancy is associated with increased demand of all the nutrients like Iron, Copper, Zinc etc. and deficiency of any of these could affect pregnancy, delivery and out come of pregnancy. With this consideration, the study was conducted on 80 mothers and newborns and 20 age matched control women. Out of 80 mothers, 34 had Iron deficiency anemia and their Hb levels were below 9.0 gm/d1. Pregnant women had significantly lower Iron and Zinc levels while Copper and Total Iron Binding Capacity (TIBC) were significantly higher (P<0.001). Newborns had significantly elevated Iron and Zinc levels and low levels of Copper and TIBC as compared to their mothers irrespective of Iron deficiency anemia. Micronutrient status of newborn was found to be dependent on their mother's micronutrient status. Besides, results also suggest micronutrient interactions, which are reflected in Iron/Zinc, Iron/Copper and Zinc/Copper ratios. In view of this, there is need for proper, adequate and balanced micronutrient supplementation during pregnancy to affect a healthy outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Black, R.E. (2001) Micronutrients in pregnancy.Br. J. Nutr. 85 (2), S193–197.

    Google Scholar 

  2. Naeye, R., Blanc, W. and Paul, C. (1973) Affects of maternal nutrition on human fetus.Pediatr. 52, 494–503.

    CAS  Google Scholar 

  3. Vanden, Brock, N.R., Letsky, E.A., White, S.A. and Shenkin, A. (1998) Iron status in pregnant women: which measurements are valid?Br J. Haematol. 103 (3), 817–24.

    Article  Google Scholar 

  4. Sharma, D.C., Kiran, R., Ramnath, V., Khushlani, K. and Singh, P.P. (1994) Iron deficiency anemia in vegetarian mothers and their newborns.Ind. J. Clin. Biochem. 9, 100–102.

    Article  Google Scholar 

  5. Perveen, S., Altaf, W., Vohra, N., Bautista, M.L., Harper, R.G. and Wapnir, R.A. (2002) Effect of gestational age on cord blood plasma copper, zinc, magnesium, and albumin.Early Hum. Dev. 69 (1–2), 15–23.

    Article  PubMed  CAS  Google Scholar 

  6. Kolsteren, P., Rahman, S.R., Hilderband, K. and Diniz, A. (1999) Treatment for Iron deficiency anemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh.Eur. J. Clin. Nutr. 53 (2), 102–106.

    Article  PubMed  CAS  Google Scholar 

  7. Sehifman, R.B., Rivers, S.L., Finley, P.R. and Thies, C. (1982) RBC, zinc, protoporphyrin to screen blood donors for iron deficiency anemia.JAMA 22. 248 (16), 2012–2015.

    Article  Google Scholar 

  8. Sharma, D.C., Ajmera, P., Sharma, S. and Sharma, P. (1999) Association between serum iron and copper in pregnant anemic vegetarian women.SDMH Jour. 23 (1): 37–39.

    Google Scholar 

  9. Salgneiro, J., Zubillage, M., Lysianek, A., Sarabia, M.I., Calmanonici, G., Caro, R., De Paoli, T., Hager, A., Weill, R. and Boccio, J. (1999). Zinc: concepts on an essential micronutrient. A trphysiol Pharmacol.Ther Latinoam. 49 (1), 1–12.

    Google Scholar 

  10. Dacie, J.V. and Lewis, S.M. (1994).Practical Hematology, 8th Ed. Churchil Livingstone, Edinburg. 49–59.

    Google Scholar 

  11. Dacie, J.V. and Lewis, S.M. (1994)Practical Hematology, 8th Ed. Churchil Livingstone, Edinburg. 60–82.

    Google Scholar 

  12. Gambling, L., Danzeisen, R., Fosset, C., Andersen, H.S., Dunford, S., Srai, S.K., and Ardle, M.H.J. (2003) Iron and copper interactions in development and the effect on pregnancy outcome.J. Nutr. 133 (5), 1554S-1556S.

    PubMed  CAS  Google Scholar 

  13. Yadric, M.K., Kenney, M.A. and Winterfeldt, E.A. (1998) Iron, copper and zinc status: Response to supplementation with zinc or zinc and Iron in adult females.Am. J. clin. Nutr. 49, 145–150.

    Google Scholar 

  14. Balai, K.S., Pendse, V., Gupta, R. and Gupta, S. (1992) Effect of maternal anemia on iron status of the newborn.Indian J. Matern. Child Health, 3 (2), 54–56.

    PubMed  CAS  Google Scholar 

  15. Islam, M.A., Hemalatha, P., Bhaskaran, P. and Kumar, P.A. (1994) Leucocyte and plasma zinc in maternal and cord blood: their relationship to period of gestation and birth weight.Nutr. Res. 14, 353–360.

    Article  CAS  Google Scholar 

  16. Sachdeva, R. and Mann, S.K. (1994) Impact of nutrition counselling and supplements on the mineral nutriture of rural pregnant women and their neonates.Indian Pediatr. 31 (6), 643–649.

    PubMed  CAS  Google Scholar 

  17. Metcoff, Costiloe, J.P. and Crosby, W. (1981) Maternal nutrition and fetal outcome.Am. J. Clin. Nutr. 34, 708–721.

    PubMed  CAS  Google Scholar 

  18. Sandstorm, B. (2001) Micronutrient Interactions: effects on absorption and bioavailability.Br. J. Nutr. 8S (2), S181–185.

    Google Scholar 

  19. Henkin, I.R., Marshall, J.R. and Meret, S. (1971) Materno fetal metabolism of copper and zinc at term.Am. J. Obstet. Gynecol. 110, 131–34.

    PubMed  CAS  Google Scholar 

  20. Aggett, P.J. and Harris, J.T. (1979) Current status of zinc in health and disease states.Arch. Dis. Chil. 54, 909–917.

    Article  CAS  Google Scholar 

  21. Bro, S., Berendtsen, H., Norgaard, J., Host, A. and Jorgensen, P.J. (1988) Serum zinc and copper concentrations in maternal and umbilical cord blood: Relation to course and outcome of pregnancy.Scand. J. Clin. Lab. Invest. 48, 805–811.

    Article  PubMed  CAS  Google Scholar 

  22. Swanson, C.A. and King, J.C. (1983) Reduced serum zinc concentration during pregnancy.Obstet. Gynecol. 62, 313–316.

    Article  PubMed  CAS  Google Scholar 

  23. Garg, H.K., Singhal, K.C. and Arshad, Z. (1994) Effect of oral zinc supplementation on copper and Hemoglobin levels in pregnant women.Ind. J. Physiol. Pharmacol. 38 (4), 272–276.

    CAS  Google Scholar 

  24. Ece, A., Uyanik, B. S., Iscan, A., Ertan, P. and Yigitoglu, M.R. (1997) Increased serum copper and decreased serum zinc levels in children with Iron deficiency anemia.Biol. Trace Elem. Re. 59 (1–3), 31–39.

    Article  CAS  Google Scholar 

  25. Dawson, E.B., Albers, J. and Ganity, M.W.J. (1989) Serum zinc changes due to Iron supplementation in teen-age pregnancy.Am. J. Clin. Nutr. 848–852.

  26. Prasad, A.S., Brewer, G.J., Schoomaker, E.B. and Rabbani, P. (1978) Hypocupremia induced by zinc therapy in adults.JAMA 240, 2166–2168.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Praveen Sharma.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Upadhyaya, C., Mishra, S., Ajmera, P. et al. Serum iron, copper and zinc status in maternal and cord blood. Indian J Clin Biochem 19, 48–52 (2004). https://doi.org/10.1007/BF02894257

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02894257

Key Words

Navigation