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Correlation of human S100A12 (EN-RAGE) and high-sensitivity C-reactive protein as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes

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Abstract

Objective

The aim of the present study was to evaluate the levels and correlation of human S100A12 and high-sensitivity C-reactive protein (hs-CRP) in gingival crevicular fluid (GCF) and serum in chronic periodontitis (CP) subjects with and without type 2 diabetes mellitus (DM).

Materials and methods

A total of 44 subjects were divided into three groups: group 1 had 10 periodontally healthy subjects, group 2 consisted of 17 CP subjects and group 3 had 17 type 2 DM subjects with CP. GCF and serum levels of human S100A12 and hs-CRP were quantified using enzyme-linked immunosorbent assay and immunoturbidimetric analysis, respectively. The clinical outcomes evaluated were gingival index, probing depth and clinical attachment level and the correlations of the two inflammatory mediators with clinical parameters were evaluated.

Results

Both human S100A12 and hs-CRP levels increased from group 1 to group 2 to group 3. The GCF and serum values of both these inflammatory mediators correlated positively with each other and with the periodontal parameters evaluated (p < 0.05).

Conclusion

Human S100A12 and hs-CRP can be considered as possible GCF and serum markers of inflammatory activity in CP and DM.

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Acknowledgments

The authors are grateful to Mr. Manjunath Sharma, Institute of Statistical Services, Bangalore for providing the statistical analysis. The authors report no conflict of interests.

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Authors and Affiliations

  1. Department of Periodontics, Government Dental College and Research Institute, Bangalore, 560002, Karnataka, India

    A. R. Pradeep, Santosh S. Martande, Sonender Pal Singh & Deepak Kumar Suke

  2. Bangalore Medical College and Research Institute, Bangalore, 560002, Karnataka, India

    Arjun P. Raju

  3. Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore, 560002, Karnataka, India

    Savitha B. Naik

Authors
  1. A. R. Pradeep
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  2. Santosh S. Martande
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  3. Sonender Pal Singh
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Correspondence to A. R. Pradeep.

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Responsible Editor: Ji Zhang.

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Pradeep, A.R., Martande, S.S., Singh, S.P. et al. Correlation of human S100A12 (EN-RAGE) and high-sensitivity C-reactive protein as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes. Inflamm. Res. 63, 317–323 (2014). https://doi.org/10.1007/s00011-013-0703-3

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  • DOI: https://doi.org/10.1007/s00011-013-0703-3

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