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Polyamines: therapeutic perspectives in oxidative stress and inflammatory diseases

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Abstract

Polyamines are naturally occurring aliphatic compounds, particularly essential elements for biological functions. These compounds play a central role in regulating molecular pathways which are responsible for cellular proliferation, growth, and differentiation. Importantly, excessive polyamine catabolism can lead to a prominent source of oxidative stress which increases inflammatory response and thought to be involved in several diseases including stroke, renal failure, neurological disease, liver disease, and even cancer. Moreover, polyamine supplementation increases life span in model organisms and may encounter oxidative stress via exerting its potential anti-oxidant and anti-inflammatory properties. The revealed literature indicates that an emerging role of polyamine biosynthetic pathway could be a novel target for drug development against inflammatory diseases. In this review, we expand the knowledge on the metabolism of polyamines, and its anti-oxidant and anti-inflammatory activities which might have future implications against inflammatory diseases in humans and animals.

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Abbreviations

ADC:

Arginine decarboxylase

TNFα:

Tumor necrosis factor α

ODC:

Ornithine decarboxylase

SRM:

Spermidine synthase

SMS:

Spermine synthase

AMD1:

Adenosylmethionine decarboxylase

SAM:

Decarboxylates S-adenosylmethionine

TGS2:

Transglutaminases

eIF-5A:

Eukaryotic initiation factor 5A

eEF1A:

Eukaryotic translation elongation factor 1A

BASO:

Bovine Albumin serum oxidase enzyme

Nrf2:

Nuclear factor (erythroid-derived 2)-like 2

LPS:

Lipopolysaccharide

ROS:

Reactive oxygen species

PI3K/Akt:

The phosphoinositide 3-kinase (PI3K)/serine/threonine-specific protein kinase (Protein kinase-B)

NF-kB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

IEC-6:

Intestinal epithelial cell line-6

SSAT:

Spermidine/spermine N1-acetyltransferase

MeSpd:

α-Methylspermidine

CECs:

Colonic epithelial cells

DSS:

Dextran sodium sulfate

EBR:

Epibrassinolide

AZI:

Antizyme inhibitor

FAD:

Flavin adenine dinucleotide

NSCLC:

(non-small cell lung cancers)

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Acknowledgements

This work was supported by the National Science and Technology Ministry (2014BAD08B11), the National Natural Science Foundation of China (nos. 31330075, 31560640, 31372326, and 31301989), and the Science and Technology Department of Hunan province (2015JC3126). We are also thankful to CAS-TWAS President’s Fellowship and UCAS financial and infrastructure support, as well as Changsha Lvye Biotechnology Limited Company Academician Expert Workstation.

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Authors and Affiliations

  1. National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, People’s Republic of China

    Tarique Hussain, Bie Tan, Wenkai Ren & Yulong Yin

  2. University of the Chinese Academy of Sciences, Beijing, 10008, People’s Republic of China

    Tarique Hussain & Wenkai Ren

  3. Department of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, 70050, Sindh, Pakistan

    Najma Rahu & Dildar Hussain Kalhoro

  4. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China

    Rahim Dad

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  1. Tarique Hussain
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Correspondence to Bie Tan or Yulong Yin.

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Hussain, T., Tan, B., Ren, W. et al. Polyamines: therapeutic perspectives in oxidative stress and inflammatory diseases. Amino Acids 49, 1457–1468 (2017). https://doi.org/10.1007/s00726-017-2447-9

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