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Expression of Surface Molecules in Human Mesenchymal Stromal Cells Co-Cultured with Nucleated Umbilical Cord Blood Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the expression of different classes of surface molecules (CD13, CD29, CD40, CD44, CD54, CD71, CD73, CD80, CD86, CD90, CD105, CD106, CD146, HLA-I, and HLA-DR) in mesenchymal stromal cells from human umbilical cord and bone marrow during co-culturing with nucleated umbilical cord blood cells. Expression of the majority of surface markers in both types of mesenchymal stromal cells was stable and did not depend on the presence of the blood cells. Significant differences were found only for cell adhesion molecules CD54 (ICAM-1) and CD106 (VCAM-1) responsible for direct cell—cell contacts with leukocytes and only for bone marrow derived cells.

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Authors and Affiliations

  1. Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia

    Yu. A. Romanov & N. V. Kabaeva

  2. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. E. Volgina & G. T. Sukhikh

  3. CryoCenter Cord Blood Bank, Moscow, Russia

    Yu. A. Romanov, E. E. Balashova & T. N. Dugina

Authors
  1. Yu. A. Romanov
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  2. E. E. Balashova
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  3. N. E. Volgina
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  4. N. V. Kabaeva
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  5. T. N. Dugina
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  6. G. T. Sukhikh
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Corresponding author

Correspondence to Yu. A. Romanov.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 270-274, October, 2016

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Romanov, Y.A., Balashova, E.E., Volgina, N.E. et al. Expression of Surface Molecules in Human Mesenchymal Stromal Cells Co-Cultured with Nucleated Umbilical Cord Blood Cells. Bull Exp Biol Med 162, 578–582 (2017). https://doi.org/10.1007/s10517-017-3662-9

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  • DOI: https://doi.org/10.1007/s10517-017-3662-9

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