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Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans

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Abstract

Purpose

To evaluate physical activity and other lifestyle risk factors in relation to the prevalence of colorectal adenomas in asymptomatic Koreans.

Methods

A total of 1,526 asymptomatic subjects who underwent a colonoscopy were enrolled. Lifestyle factors such as physical activity and smoking data were obtained using a questionnaire. The subjects were grouped into three exposure levels by tertiles of metabolic equivalent hours per week. We evaluated the risk factors in subjects with adenomas by risk stratification (low-risk adenoma group vs. high-risk adenoma group) and by anatomic location (proximal colon, distal colon, rectum, and multiple locations). The high-risk adenoma group was defined as subjects with advanced adenomas or multiple (≥3) adenomas.

Results

A total of 456 participants had colorectal adenomas, and 861 had no polyps. In multivariate analyses, higher levels of physical activity were associated with a significantly decreased risk of colorectal adenomas (OR = 0.56, 95 % CI 0.40–0.79). This inverse association was stronger for the risk of high-risk adenomas (OR = 0.39, 95 % CI 0.21–0.73) than for low-risk adenomas (OR = 0.62, 95 % CI 0.43–0.89). The negative relation of physical activity was significant for distal colon adenomas (OR = 0.54, 95 % CI 0.30–0.95) and the adenomas with multiple locations (OR = 0.39, 95 % CI 0.21–0.72).

Conclusions

Increased physical activity is associated with a reduced prevalence of colorectal adenomas. The inverse association between physical activity and adenoma was stronger for the risk of advanced or multiple adenomas.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, 39th Floor, Gangnam Finance Center, 737 Yeoksam-dong, Gangnam-gu, Seoul, 135-984, Korea

    Ji Hyun Song, Young Sun Kim, Sun Young Yang, Su Jin Chung, Min Jung Park, Seon Hee Lim & Jeong Yoon Yim

  2. Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea

    Joo Sung Kim & Hyun Chae Jung

Authors
  1. Ji Hyun Song
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  2. Young Sun Kim
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  3. Sun Young Yang
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  4. Su Jin Chung
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  5. Min Jung Park
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  8. Joo Sung Kim
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  9. Hyun Chae Jung
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Correspondence to Young Sun Kim.

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Song, J.H., Kim, Y.S., Yang, S.Y. et al. Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans. Cancer Causes Control 24, 1717–1726 (2013). https://doi.org/10.1007/s10552-013-0247-4

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  • DOI: https://doi.org/10.1007/s10552-013-0247-4

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