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3,4-Disubstituted maleimides: synthesis and biological activity

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Chemistry of Heterocyclic Compounds Aims and scope

This review is devoted to methods for the synthesis of 3,4-disubstituted maleimides – compounds that often show pronounced biological activity. We offer classification of synthetic methods, present comparative analysis of various approaches while describing their advantages and drawbacks. The areas of practical applications are indicated for several 3,4-disubstituted maleimide derivatives in the role of pharmaceutical agents or reactive dyes. The majority of the considered publications are from the last 10 years.

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This study was supported by a grant from the Russian Science Foundation (project 16-15-10300).

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Authors and Affiliations

  1. Gause Institute of New Antibiotics, 11 Build. 1, Bolshaya Pirogovskaya St., Moscow, 119021, Russia

    Alexey A. Panov, Alexander Yu. Simonov, Sergey N. Lavrenov, Sergey A. Lakatosh & Alexey S. Trenin

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  1. Alexey A. Panov
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  2. Alexander Yu. Simonov
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  3. Sergey N. Lavrenov
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  4. Sergey A. Lakatosh
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  5. Alexey S. Trenin
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Correspondence to Alexey A. Panov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(2), 103–113

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Panov, A.A., Simonov, A.Y., Lavrenov, S.N. et al. 3,4-Disubstituted maleimides: synthesis and biological activity. Chem Heterocycl Comp 54, 103–113 (2018). https://doi.org/10.1007/s10593-018-2240-z

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