Abstract
Human umbilical cord mesenchymal stem cells (hUMSC) are primitive multipotent cells capable of differentiating into cells of different lineages. They can be an alternative source of pluripotent cells since they are ethically and regulatory approved, are easily obtained and have low immunogenicity compared to embryonic stem cells which are dogged with numerous controversies. hUMSC can be a great source for cell and transplantation therapy.
Similar content being viewed by others
References
Aasen T, Raya A, Barrero MJ, Garreta E, Consiglio A, Gonzalez F, Vassena R, Bilić J, Pekarik V, Tiscornia G, Edel M, Boué S, Izpisúa Belmonte JC (2008) Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol 26:1276–1284
Anzalone R, Lo Iacono M, Corrao S, Magno F, Loria T, Cappello F, Zummo G, Farina F, La Rocca G (2010) New emerging potentials for human Wharton’s jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiate capacity. Stem Cells Dev 19:423–438
Barry FP, Murphy JM (2004) Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 36:568–584
Blank U, Karlsson G, Karlsson S (2008) Signaling pathways governing stem cell fate. Blood 111:492–503
Blum B, Benvenisty N (2005) Differentiation in vivo and in vitro of human embryonic stem cells. In: Bongso A, Lee EH (eds) Stem cells: from bench to bedside. World Scientific, Singapore, pp 123–143
Blum B, Benvenisty N (2008) The tumorigenicity of human embryonic stem cells. Adv Cancer Res 100:133–158
Brenner MK (2004) Hematopoietic stem cell transplantation for autoimmune disease; limits and future potential. Best Pract Res Clin Haematol 17:359–374
Brimble SN, Zeng X, Weiler DA, Luo Y, Liu Y, Lyons IG, Freed WJ, Robins AJ, Rao MS, Schulz TC (2004) Karyotypic stability, genotyping, differentiation, feeder-free maintenance and gene expression sampling in three human embryonic stem cells lines derived prior to Aug 9, 2001. Stem Cells Dev 13:585–595
Buja LM, Vela D (2010) Immunologic and inflammatory reactions to exogenous stem cells. J Am Coll Cardiol 56:1693–1700
Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA, Pei D (2010) Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem 285:11227–11234
Cao H, Qian H, Xu W, Zhu W, Zhang X, Chen Y, Wang M, Yan Y, Xie Y (2010) Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats. Biotechnol Lett 32:725
Chambers I, Tomlison SR (2009) The transcriptional foundation of pluripotency. Development 136:2311–2322
Chang YJ, Shih DT, Tseng CP, Hsieh TB, Lee DC, Hwang SM (2006a) Disparate mesenchyme-lineage tendencies in mesenchymal stem cells from human bone marrow and umbilical cord blood. Stem Cells 24:679–685
Chang YJ, Tseng CP, Hsu LF, Hsieh TB, Hwang SM (2006b) Characterization of two populations of mesenchymal progenitor cells in umbilical cord blood. Cell Biol Int 30:495–499
Chao KC, Chao KF, Fu YS, Liu SH (2008) Islet-like clusters derived from mesenchymal stem cells in Wharton’s Jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS ONE 3:e1451
Chen Y, Shao JZ, Xiang XL, Dong XJ, Zhang GR (2008) Mesenchymal stem cells; A promising candidate in regenerative medicine. Int J Biochem Cell Biol 40:815–820
Chunliang L, Junmei Z, Guilai S, Yu M, Yang Y, Junjie G, Hongyao Y, Shibo J, Zhe W, Fang C, Ying J (2009) Pluripotency can be rapidly and efficiently induced in human amniotic fluid derived cells. Hum Mol Genet 18:4340–4349
Dazzi F, Fozza C (2007) Diseases relapse after hematopoietic stem cell transplantation; risk factors and treatment. Best Pract Res Clin Haematol 20:311–327
Draper JS, Smith K, Gokhale P, Moore HD, Maltby E, Johnson J, Meisner L, Zwaka TP, Thomson JA, Andrew PW (2004) Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol 22:53–54
Drukker M, Katz G, Urbach A, Schuldiner M, Markel G, Itskovitz-Eldor J, Reubinoff B, Mandelboim O, Benvenisty N (2002) Characterisation of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci USA 99:9864–9869
Eggan K, Baldwin K, Tackett M, Osborne J, Gogos J, Chess A, Axel R, Jaenisch R (2004) Mice cloned from olfactory sensory neurons. Nature 428:44–49
Erices A, Conget P, Minguell JJ (2000) Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 109:235–242
Findikli N, Candan NZ, Kahraman S (2006) Human embryonic stem cell culture; current limitations and novel strategies. Reprod Biomed Online 13:581–590
Fortunel N, Batard P, Hatzfeld A, Monier MN, Panterne B, Lebkowski J, Hatzfeld J (1998) High proliferative potential quiescent cells; a working model to study primitive quiescent hematopoietic cells. J Cell Sci 111:1867–1875
Fu YS, Cheng YC, Lin MY, Cheng H, Chu PM, Chou SC, Shih YH, Ko MH, Sung MS (2006) Conversion of human umbilical cord mesenchymal stem cells in Wharton’s jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells 24:115–124
Fumio A, Toshio J (2007) Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci 1106:41–53
Gutierrez- Rodriguez M, Reyes-Maldonado E, Mayani H (2000) Characterization of the adherent cells developed in Dexter-type long-term cultures from human umbilical cord blood. Stem Cells 18:46–52
Herrero C, Pérez-Simón JA (2010) Immunomodulatory effect of mesenchymal stem cells. Braz J Med Biol Res 43:425–430
Huang X, Cho S, Spangrude GJ (2007) Hematopoietic stem cells; generation and self renewal. Cell Death Differ 14:1851–1859
Ishige I, Nagamura T, Honda MJ, Harnprsopwat R, Kido M, Sugimoto M, Nakauchi H, Tojo A (2009) Comparison of mesenchymal stem cells derived from arterial, venous and Wharton’s jelly explants of human umbilical cord. Int J Hematol 90:261–269
Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, Soreq H, Benvenisty N (2000) Differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers. Mol Med 6:88–95
Jung Y, Song J, Shiozawa Y, Wang J, Wang Z, Williams B, Havens A, Schneider A, Ge C, Franceschi RT, McCauley LK, Krebsbach PH, Taichman RS (2008) Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of stem cell niche. Stem Cells 26:2042–2051
Kang XQ, Zang WJ, Bao LJ, Li DL, Xu XL, Yu XJ (2006) Differentiating characterization of human umbilical cord blood-derived mesenchymal stem cells in vitro. Cell Biol Int 30:569–575
Karahuseyinoglu S, Cinar O, Kilic E, Kara F, Akay GG, Demiralp DO, Tukun A, Uckan D, Can A (2007) Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells 25:319–331
Kato Y, Tani T, Tsunada y (2000) Cloning of calves from various somatic cell types of male and female adult newborn and fetal cows. J Reprod Fertil 120:231–237
Kern S, Eichler H, Stoeve J, Klüter H, Bieback K (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24:1294–1301
Kim SW, Han H, Chae GT, Lee SH, Bo S, Yoon JH, Lee YS, Lee KS, Park HK, Kang KS (2006) Successful stem cell therapy using umbilical cord blood-derived multipotent stem cells for Buerger’s disease and ischemic limb disease animal model. Stem Cells 24:1620–1626
Kim JY, Jeon HB, Yang YS, Oh W, Chang JW (2010) Application of human umbilical cord blood-derived mesenchymal stem cells in disease models. World J Stem Cells 2:34–38
Kobayashi H, Butler JM, O’Donnell R, Kobayashi M, Ding BS, Bonner B, Chiu VK, Nolan DJ, Shido K, Benjamin L, Rafii S (2010) Angiocrine factors from Akt-activated endothelial cells balance self renewal and differentiation of hematopoietic stem cells. Nat Cell Biol 12:1046–1056
Konrad H, Kathrin P (2009) Epigenetic and induced pluripotency. Development 136:509–523
Krampera M, Pasini A, Pizzolo G, Cosmi L, Romagnani S, Annunziato F (2006) Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr Opin Pharmacol 6:435–4180
Lagasse E, Connors H, Dhalimy AL, Reitsma M, Dohse M, Osborne l, Wang X, Finegold M, Weissman L, Grompe M (2000) Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6:1229–1234
Lee MW, Choi J, Yang MS, Moon YJ, Park JS, Kim HC, Kim YJ (2004) Mesenchymal stem cells from cryopreserved human umbilical cord blood. Biochem Biophys Res Commun 320:273–278
Lee HJ, Lee JK, Lee H, Shin JW, Carter JE, Sakamoto T, Jin HK, Bae JS (2010) The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer’s disease. Neurosci Lett 481:30–35
Li C, Zhou J, Shi G, Ma Y, Yang Y, Gu J, Yu H, Jin S, Wei Z, Chen F, Jin Y (2009) Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells. Hum Mol Genet 18:4340–4349
Lu LL, Liu YJ, Yang SG, Zhao QJ, Wang X, Gong W, Han ZB, Xu ZS, Lu YX, Liu D, Chen ZZ, Han ZC (2006) Isolation and characterization of human umbilical cord mesenchymal stem cells with haematopoiesis-supportive function and other potentials. Haematologica 91:1017–1026
Lu X, Alshemali S, Wynter EA, Dickinson A (2010) Mesenchymal stem cells from CD34 (-) human umbilical cord blood. Transfus Med 20:178–184
Luis TC, Weerkamp F, Naber BA, Baert MR, de Haas EF, Nikolic T, Heuvelmans S, De Krijger RR, Van Dongen JJ, Staal FJ (2009) Wnt 3a deficiency irreversibly impairs hematopoietic stem cell self renewal and leads to defects in progenitor cell differentiation. Blood 113:546–554
Ma L, Feng XY, Cui BL, Law F, Jiang XW, Yang LY, Xie QD, Huang TH (2005) Human umbilical cord Wharton’s Jelly-derived mesenchymal stem cells differentiation into nerve-like cells. Chin Med J (Engl) 118:1987–1993
Magnusson M, Brun AC, Miyake N, Larsson J, Ehinger M, Bjornson JM, Wutz A, Sigvardsson M, Karlsson S (2007) HoxA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocytic development. Blood 109:3687–3696
Mareschi K, Biasin E, Piacibello W, Aglietta M, Madon E, Fagioli F (2001) Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica 86:1099–1100
Martin GR (1981) Isolation of pluripotent cell line from early mouse embryos cultures in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78:7634–7636
Martin G, Roger P (2010) Notch signaling and hematopoietic stem cell formation during embryogenesis. J Cell Physiol 222:11–16
Matsuzuka T, Rachakatla RS, Doi C, Maurya DK, Ohta N, Kawabata A, Pyle MM, Pickel L, Reishman F, Troyer D, Tamura M (2010) Human umbilical cord matrix-derived stem cells expressing interferon-β gene significantly attenuate bronchioloalveolar carcinoma xenografts in SCID mice. Lung Cancer 70:28–36
Mehrotra M, Rosol M, Ogawa M, Larue AC (2010) Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation; micro computed tomography studies. Exp Haematol 38:593–602
Micha D, Nissim B (2004) The immunogenicity of human embryonic stem derived cells. Trends Biotechnol 22:136–141
Michael H, Lars N, Justin CW (2008) The hematopoietic stem cell niche; what are we trying to replicate. J Chem Technol Biotechnol 83:421–443
Morigi M, Rota C, Montemurro T, Montelatici E, Lo Cicero V, Imberti B, Abbate M, Zoja C, Cassis P, Longaretti L, Rebulla P, Introna M, Capelli C, Benigni A, Remuzzi G, Lazzari L (2010) Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury. Stem Cells 28:513–522
Nishiyama N, Miyoshi S, Hida N, Uyama T, Okamoto K, Ikegami Y, Miyado K, Segawa K, Terai M, Sakamoto M, Ogawa S, Umezawa A (2007) The significant cardi myogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro. Stem Cells 25:2017–2024
Niwa H (2007) How is pluripotency determined and maintained? Development 134:635–646
Oh W, Kim DS, Yang YS, Lee JK (2008) Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. Cell Immunol 251:116–123
Przyboski SA (2005) Differentiation of human embryonic stem cells after transplantation in immune-deficient mice. Stem Cells 23:1242–1250
Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE (1993) Stored placental blood for unrelated bone marrow reconstitution. Blood 81:1679–1690
Sarugaser R, David L, Bakshi D, Hosseini MM, Davies JE (2005) Human umbilical cord perivascular (HUPVC) cells; a source of mesenchymal progenitors. Stem Cells 23:220–229
Seo KW, Lee SR, Bhandari DR, Roh KH, Park SB, So AY, Jung JW, Seo MS, Kang SK, Lee YS, Kang KS (2009) OCT4A contributes to the stemness and multi-potency of human umbilical cord blood-derived multipotent stem cells. Biochem Biophys Res Commun 384:120–125
Servais S, Baron F, Beguin Y (2011) Allogeneic hematopoietic stem cell transplantation (HSCT) after reduced intensity conditioning. Transfus Apher Sci 44:205–210
Seung H, Eunji G, Jeong JA, Chiyoung A, Soo H, Yang IH, Park HK, Han H, Kim H (2005) In vitro differentiation of human umbilical cord blood derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun 330:1153–1161
Sobolewski K, Bankowski E, Chyczewski L, Jaworski S (1997) Collagens and glycosaminoglycans of the Wharton’s jelly. Biol Neonate 71:11–21
Solter D (2006) From teratocarcinomas to embryonic stem cells and beyond; a history of embryonic stem cell research. Nat Rev Genet 7:319–327
Stuart H, Leonard IZ (2008) Haematopoiesis; an evolving paradigm for stem cell biology. Cell 132:631–644
Suaudeau J (2011) From embryonic stem cells to iPS - an ethical perspective. Cell Prolif 44:70–84
Sun B, Yu KR, Bhandari DR, Jung JW, Kang SK, Kang KS (2010) Human umbilical cord blood mesenchymal stem cell-derived extracellular matrix prohibits metastatic cancer cell MDA-MB-231 proliferation. Cancer Lett 296:178–185
Sykes M, Nikolic B (2005) Treatment of severe autoimmune diseases by stem-cell transplantation. Nature 435:620–627
Thomson JA, Itskovitz-Eldor Shapiro J, Waknitz SS, Swiergiel MA, Marshall JJ, Jones JM (1998) Embryonic stem cells derived from human blastocyst. Science 282:1145–1147
Till JE, Mcculloch EA (1961) A direct measurement of radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213–222
Till JE, Mcculloch EA, Siminovitch L (1963) The distribution of colony-forming cells among spleen colonies. J Cell Comp Physiol 62:327–336
Tsai SY, Clavel C, Kim S, Ang YS, Grisanti L, Lee DF, Kelley K, Rendl M (2010) Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells 28:221–228
Wagers AJ, Sherwood RI, Christensen JL, Weismann IL (2002) Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297:2256–2259
Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC, Chen CC (2004) Mesenchymal stem cells in the Wharton’s jelly of the human umbilical cord. Stem Cells 22:1330–1337
Wang M, Yang Y, Yang D, Luo F, Liang W, Guo S, Xu J (2009) The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro. Immunology 126:220–232
Wang Y, Fan H, Zhou B, Ju Z, Yu L, Guo L, Han J, Lu S (2012) Fusion of human umbilical cord mesenchymal stem cells with esophageal carcinoma cells inhibits the tumorigenicity of esophageal carcinoma cells. Int J Oncol 40:370–377
Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, Merchav S, Luo Y, Rao MS, Velagaleti G, Troyer D (2006) Human umbilical cord matrix stem cells; preliminary characterization and effect of transplantation in a rodent model of Parkinson’s disease. Stem Cells 24:781–792
Weiss ML, Anderson C, Medicetty S, Seshareddy KB, Weiss RJ, VanderWerff I, Troyer D, McIntosh KR (2008) Immune properties of human umbilical cord Wharton’s jelly-derived cells. Stem Cells 26:2865–2874
Wilmut A, Schnieke E, Mcwhir J, Kind AJ, Campbell KSH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810–813
Wilson A, Oser GM, Jaworski M, Blanco-Bose WE, Laurenti E, Adolphe C, Essers MA, Macdonald HR, Trumpp A (2007) Dormant and self renewing hematopoietic stem cells and their niches. Ann N Y Acad Sci 1106:64–75
Wu JY, Scadden DT, Kronenberg HM (2009) Role of osteoblast lineage in the bone marrow hematopoietic niches. J Bone Miner Res 24:759–764
Xie H, Ye M, Feng R, Graf T (2004) Stepwise reprogramming of B cells into macrophages. Cell 117:663–676
Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, Zhou H, Mao F (2009) Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int 29:356
Yuri AR, Veronica AS, Vladmir NS (2003) Searching for alternative sources of post natal human mesenchymal stem cells; candidate msc like cells from the umbilical cord. Stem Cells 21:105–110
Zhang YN, Lie PC, Wei X (2009) Differentiation of mesenchymal stromal cells derived from umbilical cord Wharton’s jelly into hepatocyte-like cells. Cytotherapy 11:548–558
Zhang HT, Fan J, Cai YQ, Zhao SJ, Xue S, Lin JH, Jiang XD, Xu RX (2010) Human Wharton’s jelly cells can be induced to differentiate into growth factor-secreting oligodendrocyte progenitor-like cells. Differtiation 79:15–20
Zhao Q, Ren H, Li X, Chen Z, Zhang X, Gong W, Liu Y, Pang T, Han ZC (2009) Differentiation of human umbilical cord mesenchymal stromal cells into low immunogenic hepatocyte-like cells. Cytotherapy 11:414–426
Zon LI (2008) Intrinsic and extrinsic control of hematopoietic stem cell self renewal. Nature 453:306–313
Acknowledgments
This work is supported by the National Natural Science Foundation of China (no. 81072741), National Basic Research Program of China (“973 Program”) (2011CB505300-02), Program for Changjiang Scholars and Innovative Research Team in University (no. IRT0973) and Tianjin Research Program Of Application Foundation And Advanced Technology (No.09jcybjc).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Duya, P., Bian, Y., Chu, X. et al. Stem cells for reprogramming: could hUMSCs be a better choice?. Cytotechnology 65, 335–345 (2013). https://doi.org/10.1007/s10616-012-9489-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10616-012-9489-3