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Magnetically treated water at 4 Hz and 2.5 mT as a modulator of cisplatin effect on cell hydration and ouabain binding of sarcoma-180 tissue

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Abstract

There are many data about the extremely low-frequency electromagnetic fields (ELF-EMF) therapeutic use, especially in the field of oncology. Recent data suggest that 4 Hz EMF having dehydration effect on tissues has a pronounced antitumor activity on sarcoma-180 in mice. It was shown that 4 Hz EMF have pronounced effects on physicochemical properties of water and water solution. Therefore, the aim of the present work was the comparative study of the modulation effect of ELF-EMF on cisplatin-induced changes cell hydration and number of ouabain receptors in membrane of sarcoma-180 tumor tissues. Tissue hydration was measured as wet weight/dry weight and expressed as a water content of g/g in dry weight. The number of 3H-ouabain receptors in membrane was counted by isotope scintillation counter. In conclusion, ELF-EMF can be a possible tool for stimulation of cisPt antitumor effect.

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Acknowledgments

We thank Anna Abrahamyan for help with English editing.

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Authors and Affiliations

  1. Life Sciences International Postgraduate Educational Center, Yerevan, Armenia

    L. R. Yeganyan & S. N. Ayrapetyan

  2. NAS RA the Scientific Technological Center of Organic and Pharmaceutical Chemistry SNPO, Yerevan, Armenia

    R. E. Muradyan & F. H. Arsenyan

  3. National Center of Oncology, Yerevan, Armenia

    G. K. Bazikyan

Authors
  1. L. R. Yeganyan
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  2. R. E. Muradyan
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  3. F. H. Arsenyan
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  4. G. K. Bazikyan
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  5. S. N. Ayrapetyan
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Correspondence to S. N. Ayrapetyan.

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Yeganyan, L.R., Muradyan, R.E., Arsenyan, F.H. et al. Magnetically treated water at 4 Hz and 2.5 mT as a modulator of cisplatin effect on cell hydration and ouabain binding of sarcoma-180 tissue. Environmentalist 32, 236–241 (2012). https://doi.org/10.1007/s10669-011-9378-x

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  • DOI: https://doi.org/10.1007/s10669-011-9378-x

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